159470-82-3

Usage

General Description

2-amino-2-(pyrazin-2-yl)acetic acid ethyl ester hydrochloride is a chemical compound with a molecular formula C9H12ClN3O2. It is a derivative of pyrazin-2-ylacetic acid and is commonly used in the pharmaceutical industry as a precursor for the synthesis of various drugs. 2-amino-2-(pyrazin-2-yl)acetic acid ethyl ester hydrochloride is often used as a building block in the production of pharmaceuticals and research chemicals. It is also known for its potential biological activity and has been studied for its potential use in the treatment of various diseases and conditions. Its ethyl ester hydrochloride form makes it easily soluble in organic solvents, making it suitable for various chemical reactions and applications in the laboratory.

Upstream product

• 159470-80-1 2-(diphenylmethyleneamino)-2-(pyrazin-2-yl)acetic acid ethyl ester 

Relevant academic research and scientific papers

BICYCLIC AND TRICYCLIC COMPOUNDS

Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

The acylated piperazine compound and use thereof

The present invention relates to acylated piperazine compound and its use, further relates to the pharmaceutical composition. The compound of the invention or the pharmaceutical composition can be used as dipeptidyl peptidase - IV (DPP - IV) inhibitors.

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

N-Benzyl 2-acetamido-2-substituted acetamides, where the 2-substituent is a (hetero)aromatic moiety, are potent anticonvulsants. We report the synthesis and whole animal pharmacological evaluation of 16 analogues where the terminal 2-acetyl group was removed to give the corresponding primary amino acid derivatives (PAADs). Conversion to the PAAD structure led to a substantial drop in seizure protection in animal tests, demonstrating the importance of the N-acetyl moiety for anticonvulsant activity. However, several of the PAADs displayed notable pain-attenuating activities in a mouse model.

Synthesis and anticonvulsant activities of α-acetamido-N-benzylacetamide derivatives containing an electron-deficient α-heteroaromatic substituent

Recent studies have demonstrated that C(α)-substituted α-acetamido-N- benzylacetamides displayed excellent anticonvulsant activities in mice. Analysis of the structure-activity relationship for this series of compounds has shown that placement of small, e