15948-95-5Relevant academic research and scientific papers
Method for preparing (R)-selenomethylselenocysteine
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Paragraph 0032; 0034, (2020/02/08)
The invention discloses a method for preparing (R)-selenomethylselenocysteine. The method comprises: preparing (3S,6S)-3,6-dichloromethyl-2,5-diketopiperazine; in a nitrogen atmosphere, carrying out areaction on sodium borohydride and dimethyl diselenide by using an alcohol as a solvent to generate sodium methyl selenol; carrying out a reaction on the sodium methyl selenol and the (3S,6S)-3,6-dichloromethyl-2,5-diketopiperazine to generate (3S,6S)-3,6-dimethylselenomethyl-2,5-diketopiperazine; and finally hydrolyzing the (3S,6S)-3,6-dimethylselenomethyl-2,5-diketopiperazine to generate (R)-selenomethylselenocysteine. According to the invention, the method has advantages of easily available and cheap raw materials, convenient operation, mild reaction conditions, easy product separation andhigh yield, and is suitable for industrial production.
