159486-58-5Relevant academic research and scientific papers
Monoamine - double-phenol type asymmetric trifunctional kui quinoxaline benzene and oxazine and its preparation method
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Paragraph 0022; 0023, (2018/02/04)
The invention relates to an asymmetric tri-functionality quinoxalinyl benzoxazine and a preparation method thereof. The method includes: taking 4-dihydroxy benzil and 4-nitro-o-phenylenediamine as the raw materials to synthesize a quinoxaline intermediate containing a nitro group and two phenolic hydroxyl groups, carrying out catalytic reduction to obtain monoamino-bisphenol quinoxaline, then carrying out reaction with salicylaldehyde to generate a quinoxaline triphenol compound containing an iminomethyl group, conducting reduction by sodium borohydride, and then carrying out ring-closure reaction with primary amine and paraformaldehyde, thus obtaining a monoamine-bisphenol type asymmetric tri-functionality quinoxalinyl benzoxazine monomer. By means of the excellent heat resistance of the quinoxaline molecule itself, the method introduces a flexible alkyl chain and a polymerizable group so as to make the monomer has low melting point and additional polymerization crosslinking site, thereby improving the processability, and with the introduction of more oxazine rings, the polybenzoxazine resin thereof shows excellent heat resistance and good mechanical properties, and can be used for manufacturing high performance structural materials and the like.
Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors
You, Lei,Cho, Eun Jeong,Leavitt, John,Ma, Li-Chung,Montelione, Gaetano T.,Anslyn, Eric V.,Krug, Robert M.,Ellington, Andrew,Robertus, Jon D.
supporting information; experimental part, p. 3007 - 3011 (2011/06/24)
A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. An in vitro fluorescence polarization assay demonstrated that these compounds disrupted the dsRNA-NS1A interaction to varying extents. Changes of substituent at positions 2, 3 and 6 on the quinoxaline ring led to variance in responses. The most active compounds (35 and 44) had IC50 values in the range of low micromolar concentration without exhibiting significant dsRNA intercalation. Compound 44 was able to inhibit influenza A/Udorn/72 virus growth.
