1595056-29-3Relevant academic research and scientific papers
Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series
Cox, Jason M.,Chu, Hong D.,Yang, Christine,Shen, Hong C.,Wu, Zhicai,Balsells, Jaume,Crespo, Alejandro,Brown, Patricia,Zamlynny, Beata,Wiltsie, Judyann,Clemas, Joseph,Gibson, Jack,Contino, Lisa,Lisnock, Jeanmarie,Zhou, Gaochao,Garcia-Calvo, Margarita,Bateman, Thomas,Xu, Ling,Tong, Xinchun,Crook, Martin,Sinclair, Peter
, p. 1681 - 1684 (2014/04/17)
Novel potent and selective mineralocorticoid receptor antagonists were identified, utilizing heterocyclic amide replacements in the oxazolidinedione series. Structure-activity relationship (SAR) efforts focused on improving lipophilic ligand efficiency (LLE) while maintaining nuclear hormone receptor selectivity and reasonable pharmacokinetic profiles.
