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(2-bromo-6-fluorophenyl)boronic acid pinacol ester is a chemical compound that serves as a versatile building block in organic chemistry. It features a boronic acid with a pinacol ester functional group, which is instrumental in Suzuki-Miyaura cross-coupling reactions. (2-bromo-6-fluorophenyl)boronic acid pinacol ester is characterized by the presence of bromine and fluorine atoms in the phenyl ring, offering additional functionality for further molecular modifications. Its utility extends to the synthesis of pharmaceuticals, agrochemicals, and materials, making it a valuable tool for researchers in organic synthesis.

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  • 2-(2-Bromo-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

    Cas No: 1595078-06-0

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  • 1595078-06-0 Structure
  • Basic information

    1. Product Name: (2-bromo-6-fluorophenyl)boronic acid pinacol ester
    2. Synonyms: (2-bromo-6-fluorophenyl)boronic acid pinacol ester
    3. CAS NO:1595078-06-0
    4. Molecular Formula:
    5. Molecular Weight: 300.963
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1595078-06-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2-bromo-6-fluorophenyl)boronic acid pinacol ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2-bromo-6-fluorophenyl)boronic acid pinacol ester(1595078-06-0)
    11. EPA Substance Registry System: (2-bromo-6-fluorophenyl)boronic acid pinacol ester(1595078-06-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1595078-06-0(Hazardous Substances Data)

1595078-06-0 Usage

Uses

Used in Pharmaceutical Synthesis:
(2-bromo-6-fluorophenyl)boronic acid pinacol ester is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of complex molecules with potential therapeutic applications, contributing to the development of new drugs.
Used in Agrochemical Development:
In the agrochemical industry, (2-bromo-6-fluorophenyl)boronic acid pinacol ester is utilized as a building block for the synthesis of novel compounds with pesticidal properties. Its ability to form carbon-carbon bonds through Suzuki-Miyaura cross-coupling reactions facilitates the design of innovative agrochemicals to address pest control challenges.
Used in Materials Science:
(2-bromo-6-fluorophenyl)boronic acid pinacol ester is employed as a component in the synthesis of advanced materials. Its versatility in forming biaryl compounds through cross-coupling reactions enables the development of materials with specific properties for applications in various industries, such as electronics, coatings, and plastics.
Organic Synthesis Research:
(2-bromo-6-fluorophenyl)boronic acid pinacol ester is used as a reagent in organic synthesis research. Its presence in the phenyl ring with bromine and fluorine atoms provides researchers with a platform to explore new synthetic pathways and develop innovative methodologies in organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1595078-06-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,9,5,0,7 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1595078-06:
(9*1)+(8*5)+(7*9)+(6*5)+(5*0)+(4*7)+(3*8)+(2*0)+(1*6)=200
200 % 10 = 0
So 1595078-06-0 is a valid CAS Registry Number.

1595078-06-0Downstream Products

1595078-06-0Relevant articles and documents

Use of 2-bromophenylboronic esters as benzyne precursors in the Pd-catalyzed synthesis of triphenylenes

Garcia-Lopez, Jose-Antonio,Greaney, Michael F.

supporting information, p. 2338 - 2341 (2014/05/20)

ortho-Substituted aryl boronates are introduced as aryne precursors for transition-metal-catalyzed transformations. On treatment with tBuOK and Pd(0), metal-bound aryne intermediates are formed that undergo effective trimerization to form useful triphenylene compounds. For meta-substituted arynes, the 3:1 product ratio in favor of non-C3 symmetric material is indicative of a benzyne mechanism.

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