1595086-34-2Relevant academic research and scientific papers
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
Hird, Alexander W.,Aquila, Brian M.,Block, Michael H.,Hennessy, Edward J.,Kamhi, Victor M.,Omer, Charles A.,Laing, Naomi M.,Saeh, Jamal C.,Sha, Li,Yang, Bin
, p. 1820 - 1824 (2014)
The design and synthesis of a series of novel tricyclic IAP inhibitors is reported. Rapid assembly of the core tricycle involved two key steps: Rh-catalyzed hydrogenation of an unsaturated bicyclic ring system and a Ru-catalyzed ring closing alkene metath
