159517-51-8

Basic information

• Product Name: Benzeneacetonitrile, 4-fluoro-alpha-methyl-, (S)- (9CI)
• Synonyms: Benzeneacetonitrile, 4-fluoro-alpha-methyl-, (S)- (9CI)
• CAS NO: 159517-51-8
• Molecular Formula: C₉H₈FN
• Molecular Weight: 149.1649232
• Product Categories: HALIDE
• Mol File: 159517-51-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetonitrile, 4-fluoro-alpha-methyl-, (S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 4-fluoro-alpha-methyl-, (S)- (9CI)(159517-51-8)
• EPA Substance Registry System: Benzeneacetonitrile, 4-fluoro-alpha-methyl-, (S)- (9CI)(159517-51-8)

Safety Data

• Hazardous Substances Data: 159517-51-8(Hazardous Substances Data)

Upstream product

• 706-08-1 trans-1-(4-fluorophenyl)-2-nitro-ethene 
• 459-57-4 4-fluorobenzaldehyde 
• 405-99-2 para-fluorostyrene 
• 87184-50-7 1-(1,1-dimethylethyl)-1,1-dimethyl-N-{2-(4-fluorophenyl)-1-propenylidene}silanamine 
• 51965-61-8 4-fluoro-α-methylbenzeneacetonitrile 
• 459-22-3 4-fluorophenylacetonitrile 

Relevant articles and documents

Rationalizing the Unprecedented Stereochemistry of an Enzymatic Nitrile Synthesis through a Combined Computational and Experimental Approach

In this contribution, the unique and unprecedented stereochemical phenomenon of an aldoxime dehydratase-catalyzed enantioselective dehydration of racemic E- and Z-aldoximes with selective formation of both enantiomeric forms of a chiral nitrile is rationalized by means of molecular modelling, comprising in silico mutations and docking studies. This theoretical investigation gave detailed insight into why with the same enzyme the use of racemic E- and Z-aldoximes leads to opposite forms of the chiral nitrile. The calculated mutants with a larger or smaller cavity in the active site were then prepared and used in biotransformations, showing the theoretically predicted decrease and increase of the enantioselectivities in these nitrile syntheses. This validated model also enabled the rational design of mutants with a smaller cavity, which gave superior enantioselectivities compared to the known wild-type enzyme, with excellent E-values of up to E>200 when the mutant OxdRE-Leu145Phe was utilized.

Enantioselective synthesis of (R)-2-arylpropanenitriles catalysed by ene-reductases in aqueous media and in biphasic ionic liquid-water systems

The enantioselective reduction of α-methylene nitrile derivatives catalysed by ene-reductases affords the corresponding (R)-2-arylpropanenitriles with high conversion values. The reaction is investigated either in aqueous medium (with an organic cosolvent or by loading the substrate onto hydrophobic resins) or in a biphasic ionic liquid-water system. The use of ionic liquids, herein with isolated ene-reductases, is found to improve the work-up and the substrate recovery method. The synthetic manipulation of the final chiral nitrile derivatives indicates how this biocatalysed method can be exploited for the preparation of a wide range of chiral compounds.