15952-61-1

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloropiperonal is used as an intermediate in the production of various pharmaceuticals for its medicinal properties. It plays a crucial role in the synthesis of drug products, contributing to the development of new and effective treatments.
Used in Organic Compounds Synthesis:
6-Chloropiperonal is utilized as a key component in the synthesis of various organic compounds, showcasing its versatility and importance in the field of organic chemistry.
Used in Agrochemicals Production:
6-Chloropiperonal also serves as an intermediate in the production of agrochemicals, highlighting its application in the agricultural sector to develop products that enhance crop protection and yield.

InChI:InChI=1/C8H5ClO3/c9-6-2-8-7(11-4-12-8)1-5(6)3-10/h1-3H,4H2

Upstream product

• 120-57-0 piperonal 
• 2591-25-5 6-chloro-3,4-methylenedioxybenzyl alcohol 
• 23126-68-3 6-amino-benzo[1,3]dioxole-5-carbaldehyde 
• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 

Downstream Products

• 6316-29-6 3t-(6-chloro-benzo[1,3]dioxol-5-yl)-2-phenyl-acrylic acid ethyl ester 
• 2591-25-5 6-chloro-3,4-methylenedioxybenzyl alcohol 
• 41001-58-5 (2-chloro-4,5-methylenedioxy-benzyliden)-aniline 
• 55042-85-8 2-chloro-4,5-methylenedioxy-trans-chalcone 
• 6309-47-3 5-chloro-6-diacetoxymethyl-benzo[1,3]dioxole 
• 123541-09-3 C₉H₉ClN₄O₃*C₇H₈O₃S 
• 24033-10-1 [1-(6-Chloro-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine 
• 1135318-46-5 7-(p-methoxyphenyl)-[1,3]-dioxolo[4,5-g]isoquinoline 
• 1616119-27-7 (E)-ethyl 2-(3-(6-chlorobenzo[d][1,3]dioxol-5-yl)acrylamido)cyclohex-1-enecarboxylate 

Relevant academic research and scientific papers

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis

A series of eleven 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones (16-27) was synthesised as part of a study to search for potential new drugs with a leishmanicidal effect. The thiosemicarbazones, ten of which are new compounds, were prepared in good yields (85-98%) by the reaction of 3,4-methylenedioxyde-6-benzaldehydes (6-X-piperonal), previously synthesised for this work by several methodologies, and thiosemicarbazide in ethanol with a few drops of H2SO4. These compounds were evaluated against Leishmania amazonensis promastigotes, and derivatives where X = I (22) and X = CN (23) moieties showed impressive results, having IC50 = 20.74 μM and 16.40 μM, respectively. The intracellular amastigotes assays showed IC50 = 22.00 μM (22) and 17.00 μM (23), and selectivity index >5.7 and >7.4, respectively, with a lower toxicity compared to pentamidine (positive control, SI = 4.5). The results obtained from the preliminary QSAR study indicated the hydrophobicity (log P) as a fundamental parameter for the 2D-QSAR linear model. A molecular docking study demonstrated that both compounds interact with flavin mononucleotide (FMN), important binding site of NO synthase.

Bis(sym-collidine)bromine(I) hexafluorophosphate as oxidant

Primary and secondary alcohols in solution in methylene chloride are oxidised with bis(sym-collidine)bromine(I) hexafluorophosphate in good yields to the carbonyl compounds. For secondary and tertiary alcohols in which one of the substituents is a 4-methoxyphenyl group the oxidation takes place by cleavage of the phenyl-sp3 carbon bond and formation of bromoanisole and carbonyl compounds. (C) 2000 Elsevier Science Ltd.