1595284-23-3

Upstream product

• 109-77-3 malononitrile 
• 883949-60-8 3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-2-yl)-3-oxopropanenitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 85-44-9 phthalic anhydride 
• 140-87-4 Cyanoacetohydrazide 
• 88-95-9 Phthaloyl dichloride 

Relevant academic research and scientific papers

Self-Catalyzed One-Pot Four-Component Green Synthesis of 2-Amino-6-[1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl]-4-phenyl-4H-pyran-3,5-dicarbonitriles

The title compounds were synthesized in good yields by one-pot four-component condensation of phthaloyl dichloride, ethyl cyanoacetohydrazide, malononitrile, and substituted benzaldehydes in boiling ethanol for 1–2 h. The reaction involves in situ generat

One pot, three-component synthesis of novel 3,4-dihydrophthalazin-2(1H)-yl- 4-phenyl-4H-pyrans

Green and efficient one pot, three-component synthesis of novel 2-amino-6-(1,4-dioxo-3,4-dihydrophthalazin)-2(1H)-yl-4-phenyl-4H-pyran-3, 5-dicarbonitriles 6 has been developed by condensing 3-(1,4-dioxo-3,4- dihydrophthalazin-(1H)-yl)-3-oxopropanenitrile 3, benzaldehydes 4 and active methylene compounds 5 using l-proline as catalyst in EtOH at RT.