159531-07-4

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 159531-04-1 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanal 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 159531-01-8 ethyl 2-(4-t-butylcyclohexylidene)-3-(trimethylsilyl)propanoate 
• 306326-65-8 2-(4-t-butylcyclohexylidene)-3-trimethylsilyl-1-propanol 
• 110481-61-3 3-trimethylsilyl-2-diethylphosphonopropionic acid ethyl ester 

Downstream Products

• 159531-10-9 4-(4-t-butylcyclohexylidene)-5-(trimethylsilyl)pent-1-en-3-one 

Relevant academic research and scientific papers

Nazarov cyclization of 4-cycloalkylidene-5-(trimethylsilyl)pent-1-en-3-one derivatives. Synthesis of spiro[4.5]decane, Spiro[4.4]nonane, and Their derivatives

Spiro[4.5]decane and spiro[4.4]nonane ring systems were synthesized by FeCl3-induced Nazarov cyclization of α-(trimethylsilylmethyl)divinyl ketone derivatives. It was found that the double bond position of the product is controlled by the presence/absence of α'-substituent, while trimethylsilyl group is essential to obtain the products in good yields. Spiro[4.4]nonanes having exo-methylene group underwent rearrangement to bicyclo[4.3.0]nonanes. (C) 2000 Elsevier Science Ltd.

Synthesis of spiro[4.5]decane ring system through allylsilane promoted spiroannulation

Spiro[4.5]decane ring system with methylene ketone on five membered ring was synthesized by Nazarov cyclization of α-(trimethylsilylmethyl)divinyl ketone derivatives.