159557-23-0

Usage

Aromatic benzimidazole ring

The chemical compound has a ring structure consisting of a benzene ring fused to a nitrogen-containing imidazole ring.

Piperidine group

The compound contains a piperidine group (a six-membered ring with one nitrogen atom) attached to the benzimidazole ring.

Derivative of benzimidazole

The compound is a modified version of the benzimidazole heterocyclic compound, commonly used in medicinal chemistry.

Potential pharmaceutical applications

The presence of the piperidine group suggests that the compound may have potential pharmaceutical applications, such as central nervous system agents and analgesics.

Phenylmethyl group

The compound contains a phenylmethyl group (a benzene ring attached to a methyl group), which adds complexity and potentially increases pharmacological activity or target receptor binding affinity.

Research and testing required

Further research and testing are needed to determine the specific properties and potential uses of this chemical.

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 361979-66-0 (4-benzyl-piperidin-1-yl)acetic acid ethyl ester 
• 154028-50-9 1-(2-trimethylsilylethoxymethyl)-1H-benzoimidazole-2-carbaldehyde 
• 107-06-2 1,2-dichloro-ethane 
• 4857-04-9 2-chloromethyl-1H-benzimidazole 

Downstream Products

• 952056-51-8 2-(4-Benzyl-piperidin-1-ylmethyl)-1-(4-bromo-benzyl)-1H-benzimidazole 

Relevant academic research and scientific papers

Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators

Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

NR2B-Selective N-Methyl-D-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles

Two classes of 5-substituted benzimidazoles were identified as potent antagonists of the NR2B subtype of the N-methyl-D-aspartate (NMDA) receptor. Selected compounds show very good selectivity versus the NR2A, NR2C, and NR2D subtypes of the NMDA receptor as well as versus hERG-channel activity and α1-adrenergic binding. Benzimidazole 37a shows excellent activity in the carrageenan-induced mechanical hyperalgesia assay in rats as well as good pharmacokinetic behavior in dogs.

1,4 substituted piperidinyl NMDA/NR2B antagonists

Novel piperidinyl compounds substituted in the 1- and 4-positions are effective as NMDA NR2B antagonists useful for relieving pain.

Method to treat pain utilizing benzimidazole NMDA/NR2B antagonists

Substituted benzimidazole derivatives that are NMDA NR2B antagonists are utilized to treat pain.

Benzimidazole derivatives

The invention is directed to substituted benzimidazole compounds which are ligands for dopamine receptor subtypes used in the treatment of the dopamine system.