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159583-16-1

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159583-16-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 159583-16-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,5,8 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 159583-16:
(8*1)+(7*5)+(6*9)+(5*5)+(4*8)+(3*3)+(2*1)+(1*6)=171
171 % 10 = 1
So 159583-16-1 is a valid CAS Registry Number.

159583-16-1Upstream product

159583-16-1Downstream Products

159583-16-1Relevant articles and documents

mGluR1 antagonists as therapeutic agents

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Page/Page column 84; 93, (2008/06/13)

In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1—R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

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