1596-17-4Relevant academic research and scientific papers
Base catalyzed Mitsunobu reactions as a tool for the synthesis of aryl sec-alkyl ethers
Manivel, Pitchai,Rai, Neithnadka Premsai,Jayashankara, Vaderapura Puttaramegowda,Arunachalam, Pirama Nayagam
, p. 2701 - 2705 (2007)
A facile and versatile method for the synthesis of aryl sec-alkyl ethers from phenols with alcohols in the presence of base via a Mitsunobu reaction is described.
Azodicarbonyl dimorpholide (ADDM): An effective, versatile, and water-soluble Mitsunobu reagent
Lanning, Maryanna E.,Fletcher, Steven
, p. 4624 - 4628 (2013/08/23)
One of the caveats of the Mitsunobu reaction is the often difficult and laborious purification of the reaction mixture. Herein, we show that azodicarbonyl dimorpholide (ADDM) is an effective and versatile Mitsunobu reagent, which, along with its reduced form ADDM-H2, may be removed from the reaction mixture by a simple aqueous extraction. Furthermore, we demonstrate that the isolated ADDM-H2 may be re-oxidized with silver(I) oxide to regenerate ADDM. Finally, a chromatography-free Mitsunobu reaction is presented.
