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5,6,7,8-tetrahydrofolate, also known as tetrahydrofolate or THF, is a key molecule in the folate metabolic pathway. It is an essential cofactor for various enzymes involved in the synthesis and metabolism of nucleic acids, amino acids, and neurotransmitters. Tetrahydrofolate plays a crucial role in the conversion of homocysteine to methionine, which is vital for the production of proteins and the methylation of DNA. This process is essential for maintaining proper gene expression and preventing genetic mutations. Additionally, tetrahydrofolate is involved in the production of formate, which is a precursor for the synthesis of purines and pyrimidines, the building blocks of DNA and RNA. Due to its critical role in cellular metabolism, tetrahydrofolate is an important nutrient for human health, and deficiencies can lead to various health issues, including anemia and neural tube defects.

1596-88-9

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1596-88-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1596-88-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,9 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1596-88:
(6*1)+(5*5)+(4*9)+(3*6)+(2*8)+(1*8)=109
109 % 10 = 9
So 1596-88-9 is a valid CAS Registry Number.

1596-88-9Downstream Products

1596-88-9Relevant academic research and scientific papers

The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer

Stojkovic, Vanja,Perissinotti, Laura L.,Lee, Jeeyeon,Benkovic, Stephen J.,Kohen, Amnon

, p. 8974 - 8976 (2010)

Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling.

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