15962-85-3Relevant academic research and scientific papers
Selective oxidation of propargylic alcohols into α,β-acetylenic aldehydes with a TiCl4/Et3N system
Han,Shinokubo,Oshima
, p. 1421 - 1422 (2001)
A TiCl4/Et3N combination proved to be effective for the selective oxidation of propargylic alcohols into α,β-acetylenic aldehydes in good yields. Treatment of 2-hexyne-1,6-diol with TiCl4/Et3N provided 6-hydroxy-2-hexynal in good yield.
Pinacol coupling reaction of beta-halo-alpha,beta-unsaturated aldehydes promoted by TiI4.
Shimizu, Makoto,Goto, Hiroshi,Hayakawa, Ryuuichirou
, p. 4097 - 4099 (2007/10/03)
The pinacol reaction of beta-halogenated alpha,beta-unsaturated aldehydes was promoted by titanium tetraiodide to give coupling products in good yields with high dl-selectivity. Subsequent reduction with H(2)/Pd-C gave saturated vic-diols in good yields. Heck coupling reaction enabled the displacement of halogens with vinyl groups without the loss of stereochemical integrities. [reaction: see text]
