159634-94-3

Basic information

• Product Name: D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]-
• Synonyms: D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]-;D-Tryptophan,N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl-(9CI);N-[N-[(1,1-Dimethylethoxy)carbonyl]-2-methylalanyl]-D-tryptophan;D-Tryptophan, N-[(1,1-diMethylethoxy)carbonyl]-2-Methylalanyl-;Anamorelin Intermediate 4
• CAS NO: 159634-94-3
• Molecular Formula: C₂₀H₂₇N₃O₅
• Molecular Weight: 389.45
• Product Categories: API intermediates
• Mol File: 159634-94-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 664.2±55.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.49±0.10(Predicted)
• CAS DataBase Reference: D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]-(159634-94-3)
• EPA Substance Registry System: D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]-(159634-94-3)

Safety Data

• Hazardous Substances Data: 159634-94-3(Hazardous Substances Data)

Usage

General Description

D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]- is a chemical compound that is commonly used in the field of biochemistry and pharmaceutical research. It is a derivative of the amino acid tryptophan and is often used as a building block for the synthesis of complex molecules, such as peptides and proteins. D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]- is known for its role in the formation of peptide bonds and its ability to influence the structure and function of proteins. Additionally, D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]- has been studied for its potential therapeutic applications in various diseases and disorders, making it an important compound in the development of new drugs and treatments.

Upstream product

• 14907-27-8 (R)-(+)-tryptophan methyl ester hydrochloride 
• 30992-29-1 Boc-Aib-OH 
• 153-94-6 D-tryptophan 
• 126090-33-3 (R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid benzyl ester 
• 141595-98-4 D-tryptophan benzyl ester 
• 5241-64-5 Boc-D-Trp-OH 
• 159634-93-2 (R)-α-[(2-t-Butoxycarbonylamino-2-methyl-1-oxopropyl)amino]-1H-indole-3-propanoic acid, benzyl ester 

Downstream Products

• 220541-31-1 ethyl 2-[4-((2R)-2-(2-[(tert-butoxy)carbonylamino]-2-methylpropanoylamino)-3-indol-3-ylpropanoylamino)imidazolyl]-2-phenylacetate 
• 220540-73-8 N-((1R)-2-Indol-3-yl-1-{N-[1-(2-oxo-1-phenyl-2-pyrrolidinylethyl)imidazol-4-yl]carbamoyl}ethyl)-2-[(tert-butoxy)carbonylamino]-2-methylpropanamide 
• 339539-90-1 (R,R)-{1-[2-[3-benzyl-3-(N,N',N'-trimethyl-hydrazinocarbonyl)piperidin-1-yl]-1-(1H-indol-3-ylmethyl)-2-oxo-ethylcarbamoyl]-1-methylethyl}carbamic acid tert-butyl ester 
• 883572-59-6 (S,R)-{1-[2-[3-benzyl-3-(N,N',N'-trimethyl-hydrazinocarbonyl)piperidin-1-yl]-1-(1H-indol-3-ylmethyl)-2-oxo-ethylcarbamoyl]-1-methylethyl}carbamic acid tert-butyl ester 
• 339539-92-3 RC-1291 fumarate 
• 249921-19-5 Anamorelin 
• 1415235-84-5 tert-butyl 1-((2R)-3-(1H-indol-3-yl)-1-(2-isopropyl-1-oxo-4-phenyl-2,7-diazaspiro[4.5]decan-7-yl)-1-oxopropan-2-ylamino)-2-methyl-1-oxopropan-2-ylcarbamate 
• 1415235-76-5 tert-butyl 1-((2R)-1-(4-(4-fluorophenyl)-2-methyl-1-oxo-2,7-diazaspiro[4.5]decan-7-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-2-methyl-1-oxopropan-2-ylcarbamate 
• 1415234-49-9 2-amino-N-((2R)-1-(4-(4-fluorophenyl)-2-methyl-1-oxo-2,7-diazaspiro[4.5]decan-7-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methylpropanamide 
• 185525-56-8 N-[1(R)-[(spiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(indol-3-yl)ethyl]-2-[[(1,1-dimethylethyloxy)carbonyl]amino ]-2-methylpropanamide 
• 220530-51-8 C₃₄H₄₃N₇O₆ 
• 220534-00-9 C₃₉H₄₄N₆O₆ 
• 220530-33-6 C₃₆H₄₅N₇O₆ 

Relevant articles and documents

A practical synthesis of the pseudotripeptide RC-1291

The rapid process development of a scaleable synthesis of the pseudotripeptide RC-1291 for preclinical and clinical evaluation is described. By employing a nontraditional N-to-C coupling strategy, the peptide chain of RC-1291 was assembled in high yield, with minimal racemization and in an economical manner by introducing the most expensive component last. A one-pot deprotection/crystallization procedure was developed for the isolation of RC-1291 free base, which afforded the target compound in excellent yield and with a purity of >99.5% without chromatographic purification.

Heterocyclic compounds

This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are useful for the treatment and prevention of osteoporosis, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintanence of skin thickness, metabolic homeostasis or renal homeostasis. The compounds of the present invention are also useful in treating osteoporosis when used in combination with: a bisphosphonate compound such as alendronate; estrogen, premarin, and optionally progesterone; an estrogen agonist or antagonist; or calcitonin, and pharmaceutical compositions useful therefor. Further, the present invention is directed to pharmaceutical compositions useful for increasing the endogenous production or release of growth hormone in a human or other animal which comprises an effective amount of a compound of the present invention and a growth hormone secretagogue selected from GHRP-6, Hexarelin, GHRP-1, growth hormone releasing factor (GRF), IGF-1, IGF-2 or B-HT920. The invention is also directed to intermediates useful in the preparation of compounds of formula I.

Biphenyl substituted dipeptide analogs promote release of growth hormone

There are disclosed certain compounds identified as substituted dipeptide analogs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such substituted dipeptide analogs as the active ingredient thereof are also disclosed.