159635-22-0

Basic information

• Product Name: tert-butyl3-hydroxy-4-methyleneiperidine-1-carboxylate
• Synonyms: tert-butyl3-hydroxy-4-methyleneiperidine-1-carboxylate;1-Boc-3-hydroxy-4-Methylenepiperidine;tert-Butyl 3-hydroxy-4-Methylenepiperidine-1-carboxylate;N-t-BOC-4-Methylene-3-Piperidinol;tert-butyl 3-hydroxy-4-methylidenepiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-hydroxy-4-methylene-, 1,1-dimethylethyl ester
• CAS NO: 159635-22-0
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.27346
• Mol File: 159635-22-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 309.018°C at 760 mmHg
• Flash Point: 140.689°C
• Appearance: /
• Density: 1.092g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: 2-8°C
• PKA: 14.29±0.20(Predicted)
• CAS DataBase Reference: tert-butyl3-hydroxy-4-methyleneiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl3-hydroxy-4-methyleneiperidine-1-carboxylate(159635-22-0)
• EPA Substance Registry System: tert-butyl3-hydroxy-4-methyleneiperidine-1-carboxylate(159635-22-0)

Safety Data

• Hazardous Substances Data: 159635-22-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl 3-hydroxy-4-methyleneiperidine-1-carboxylate is a chemical compound with the molecular formula C12H21NO3. It is a derivative of the amino acid pipecolic acid and has a tert-butyl group attached to the nitrogen atom. tert-butyl3-hydroxy-4-methyleneiperidine-1-carboxylate is commonly used as a reagent in organic synthesis and pharmaceutical research. It has been studied for its potential as a building block in the synthesis of various bioactive compounds and pharmaceutical drugs. Tert-butyl 3-hydroxy-4-methyleneiperidine-1-carboxylate is a versatile and important chemical in the field of organic chemistry and drug development.

InChI:InChI=1/C11H19NO3/c1-8-5-6-12(7-9(8)13)10(14)15-11(2,3)4/h9,13H,1,5-7H2,2-4H3

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 221142-27-4 4-benzenesulfinylmethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 109-72-8 n-butyllithium 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 

Downstream Products

• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 1290050-27-9 4-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-5-oxo-[1,4]diazepane-1-carboxylic acid (3-chloro-phenyl)-amide 
• 1290050-56-4 (S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide 
• 1290049-14-7 (S)-4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3,4-dichloro-phenyl)-amide 
• 1290049-74-9 (S)-4-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-1-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-3-oxo-propyl]-3-methyl-piperazin-2-one 
• 1290048-74-6 (S)-4-[(R,S)-3-Hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester 
• 1290048-29-1 4-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester 
• 1101840-74-7 4-Oxo-6-aza-spiro[2,5]octane-6-carboxylic acid tert-butyl ester 
• 1101840-72-5 tert-butyl 4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate 
• 1103501-89-8 (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride 
• 849766-92-3 3-(tert-butyl-dimethyl-silanyloxy)-4-(3,4-dichloro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS

The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particulalrly FabI inhibitors. Formula(I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS

The present invention is directed to a compound of Formula (I): (I) or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, useful as tryptase inhibitors.

Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists

Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is —C(═O)—, —C(═S)—, —(CH2)q—, —C(═NOR7)— or —SO1-2—; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, alkyl, alkenyl, or optionally substituted cycloalkyl, aryl, heteroaryl, heterocycloalkyl or a group of the formula: where ring A is a monoheteroaryl ring; R1 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome nonalcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma or cognition deficit disorders using said compounds, alone or in combination with other agents.