1596358-15-4

Basic information

• Product Name: N'-hydroxybutanimidamide
• Synonyms: N'-hydroxybutanimidamide;(1Z)-N-hydroxybutanimidamide
• CAS NO: 1596358-15-4
• Molecular Formula: C4H10N2O
• Molecular Weight: 102.135
• Mol File: 1596358-15-4.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N'-hydroxybutanimidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-hydroxybutanimidamide(1596358-15-4)
• EPA Substance Registry System: N'-hydroxybutanimidamide(1596358-15-4)

Safety Data

• Hazardous Substances Data: 1596358-15-4(Hazardous Substances Data)

Upstream product

• 109-74-0 propyl cyanide 

Downstream Products

• 139964-24-2 methyl 4-ethyl-2-propylimidazole-5-carboxylate 
• 101596-22-9 3-phenyl-5-propyl-4H-1,2,4-triazole 
• 313982-18-2 3-propyl-5-(4'-nitrophenyl)-1,2,4-oxadiazole 

Relevant articles and documents

OXADIAZOLE COMPOUNDS

The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1,R2,R3,L1,L2,L3,L4,L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.

One-Pot Synthesis of N-Monosubstituted Ureas from Nitriles via Tiemann Rearrangement

Amidoximes, obtained from the reaction of nitriles with hydroxylamine, underwent Tiemann rearrangement in the presence of benzenesulfonyl chlorides (TsCl or o-NsCl) to form the N-substituted cyanamides. Subsequently, acidic hydrolysis of the cyanamides afforded the corresponding N-monosubstituted ureas. The synthesis of N-monosubstituted ureas from nitriles was accomplished by three steps in one pot, which provides a direct access to versatile N-monosubstituted urea derivatives from a wide variety of nitriles.

Practical synthesis of N -substituted cyanamides via tiemann rearrangement of amidoximes

A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.