15965-72-7

Usage

Chemical Structure

Contains a benzimidazolone ring with a chlorine atom and a methyl group attached.

Derivative of

Benzimidazolone

Functional Groups

Chlorine atom (-Cl), methyl group (-CH3)

Application

Used in pharmaceutical and research fields.

Potential Uses

Drug development
Research tool in the study of biological processes

Properties

Specific properties may include pharmacological activity, solubility, stability, etc.
Exact properties still under investigation.

Future Potential

Potential future applications may arise as more research is conducted.

InChI:InChI=1/C8H7ClN2O/c1-11-7-4-5(9)2-3-6(7)10-8(11)12/h2-4H,1H3,(H,10,12)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 84859-27-8 5-chloro-N¹-methylbenzene-1,2-diamine 

Relevant academic research and scientific papers

2, 4-DI-(NITROGEN CONTAINING GROUP) SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF

Provided are a 2, 4-di-(nitrogen containing group) substituted pyrimidine compound represented by a general formula (I), a pharmaceutically acceptable salt and a stereoisomer thereof, a preparation method thereof, and a use thereof in preparation of anti-tumor drugs. The compound having a structural feature shown in the general formula (I) can selectively suppress activity of mutant epidermal growth factor receptors (EGFR), including single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. The compound has a weak suppression effect on wild-type EFGR and a very high selectivity, and thus it has a potential to be used in preparation of drugs for treating EGFR mutant tumors, especially non-small cell lung cancer (NSCLC) comprising a T790M EGFR mutation.

MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.