159650-16-5

Basic information

• Product Name: 1-{2-(2,4-dichlorophenyl)-2-[(3-methylbut-2-en-1-yl)oxy]ethyl}-1H-imidazole
• Synonyms: 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(3-methyl-2-buten-1-yl)oxy]ethyl]-
• CAS NO: 159650-16-5
• Molecular Formula: C₁₆H₁₈Cl₂N₂O
• Molecular Weight: 325.2329
• Mol File: 159650-16-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 471.5°C at 760 mmHg
• Flash Point: 238.9°C
• Density: 1.19g/cm³
• Vapor Pressure: 1.32E-08mmHg at 25°C
• Refractive Index: 1.563
• PKA: 6.72±0.12(Predicted)
• CAS DataBase Reference: 1-{2-(2,4-dichlorophenyl)-2-[(3-methylbut-2-en-1-yl)oxy]ethyl}-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{2-(2,4-dichlorophenyl)-2-[(3-methylbut-2-en-1-yl)oxy]ethyl}-1H-imidazole(159650-16-5)
• EPA Substance Registry System: 1-{2-(2,4-dichlorophenyl)-2-[(3-methylbut-2-en-1-yl)oxy]ethyl}-1H-imidazole(159650-16-5)

Safety Data

• Hazardous Substances Data: 159650-16-5(Hazardous Substances Data)

Upstream product

• 24155-42-8 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol 
• 870-63-3 prenyl bromide 

Relevant articles and documents

Design and synthesis of novel imidazole derivatives as potent inhibitors of allene oxide synthase(CYP74)

Allene oxide synthase (AOS) is a key enzyme in the oxylipin pathway in plants leading to jasmonic acid and other jasmonates (JAs), important signal mediators of defense signal networks in plants. AOS uses hydroperoxylinolenic acid as an oxygen donor as we

Structure-activity relationships of a new antifungal imidazole, AFK-108, and related compounds

Fungicidal activity of widely used imidazole antifungal drugs in topical applications is not so strong in spite of their potent fungistatic activities against dermatophytes and pathogenic yeasts. In order to improve fungicidal activity of imidazole antifungal agents, a series of novel imidazole derivatives having a hydrophobic substituent derived from isoprenoid were synthesized. The efficacy of these compounds was evaluated with respect to direct cell-membrane damaging activity, ergosterol biosynthesis inhibition, minimum growth-inhibitory concentration (MIC) and therapeutic effect for experimental dermatophytosis of guinea pigs. Among the newly synthesized compounds, the geranyl derivative named AFK-108 (2a) showed the highest in vivo fungicidal activity with both cell membrane damaging activity and ergosterol biosynthesis inhibition in vitro.