159663-34-0Relevant academic research and scientific papers
Biosynthesis of the benz[a]anthraquinone antibiotic PD 116198
Gould,Cheng
, p. 11135 - 11144 (1993)
The labelling pattern obtained from incorporation of a mixture of sodium [1-13C]- and [2-13C]acetates has confirmed the irregular derivation of the benz[a]anthraquinone skeleton of the angucycline antibiotic PD 116198. Subsequent incorporations of sodium [1-13C, 18O2]-, and [1-13C, 2-2H3]acetates and of 18O2 have revealed the origins of the hydrogen and oxygen atoms of the antibiotic. The possibility of a 'two-chain' biosynthesis was tested by feeding 2H-labeled orsellinates; however, no incorporation was detected. PD 116198 seems most plausibly derived by rearrangement of an initially-formed linear tetracyclic intermediate.
Diastereoselective synthesis of a methylated derivative of phomozin, a phytotoxin isolated from phonopsis helianthi, a phytopathogenic fungus of sunflowers
Nouguier,Bertrand,Picon,Perfetti
, p. 8171 - 8172 (1994)
A methylated derivative of the phytotoxin phomozin (2) is synthesized in high yield via the regioselective coupling of 2-methyl-4-benzyl orsellinic acid (6) and (R*, R*) benzyl dimethylglycerate (9) and one step hydrogenolysis of the benzyl and benzoyl protection.
