159665-22-2Relevant academic research and scientific papers
Functional Zinc Complexes of Tris(imidazolylmethyl)amine Ligands
Hartmann, Uwe,Gregorzik, Ralf,Vahrenkamp, Heinrich
, p. 2123 - 2128 (2007/10/02)
The three N-R-substituted tris(benzimidazolylmethyl)amine ligands L (1a: R = H, 1b: R = Me, 1c: R = Bz) form zinc complexes with biologically active ligands of the fifth coordination site, starting from L, Zn(ClO4)2, and the coligand.The N-protected amino acids glycine, histidine, and cysteine yield ClO4 (2a, 3a, 4a).Aspirin, salicylic acid, and orotic acid are incorporated as ClO4 (5a-c: X = O-acetylsalicylate, 6a: X = salicylate, 7a-c: X = orotate).Similarly the sulfonamide furosemide is bound by its carboxylate function in ClO4 (8a-c).The aqua complex resulting from ligand 1a and Zn(ClO4)2 forms hydrogen bonds to nitriles and aldehydes, which has allowed the isolation of (ClO4)2 (9a: RCN = MeCN, 10a: RCN = PrCN) and of (ClO4)2 (11a: RCHO = anisaldehyde, 12a: RCHO = p-tolualdehyde).The structure determination of the salicylate complex 6a has confirmed the monodentate O-coordination of the carboxylate substrates to zinc. - Key Words: Zinc complexes / Encapsulating ligands / Bioligands / Structure
