159684-36-3Relevant academic research and scientific papers
Catalytic enantioselective fluorination of oxindoles
Hamashima, Yoshitaka,Suzuki, Toshiaki,Takano, Hisashi,Shimura, Yuta,Sodeoka, Mikiko
, p. 10164 - 10165 (2007/10/03)
We have developed a highly efficient catalytic enantioselective fluorination of oxindole derivatives. In the presence of a catalytic amount of chiral Pd complex 2 (2.5 mol %), various substrates, including aryl- and alkyl-substituted oxindoles, were fluor
A General Method for the Synthesis of Isatins: Preparation of Regiospecifically Functionalized Isatins from Anilines
Hewawasam, Piyasena,Meanwell, Nicholas A.
, p. 7303 - 7306 (2007/10/02)
A new method has been developed for regiospecific conversion of substituted anilines to isatins.The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with diethyl oxalate to furnish an α-ketoester.Hydrolytic deprotection of the amino moiety is accompanied by cyclization to provide the isatin.
