159689-88-0

Basic information

• Product Name: 3-(Trifluoromethoxy)benzyl bromide
• Synonyms: 1-(BROMOMETHYL)-3-(TRIFLUOROMETHOXY)BENZENE;alpha-Bromo-3-(trifluoromethoxy)toluene;a-Bromo-3-(trifluoromethoxy)toluene;à-bromo-3-(trifluoromethoxy)toluene;3-(Trifluoromethoxy)benzyl bromide 97%;3-(Trifluoromethoxy)benzylbromide97%;1-(Bromomethyl)-3-(trifluoromethoxy)benzene, alpha-Bromo-3-(trifluoromethoxy)toluene;3-(TRIFLUOROMETHOXY)BENZYL BROMIDE
• CAS NO: 159689-88-0
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.03
• Product Categories: Ethers;Organic Building Blocks;Oxygen Compounds;Building Blocks;C2 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Fluorine series
• Mol File: 159689-88-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 179 °C(lit.)
• Flash Point: 192 °F
• Appearance: cream
• Density: 1.572 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.478(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive: Lachrymatory
• BRN: 8052203
• CAS DataBase Reference: 3-(Trifluoromethoxy)benzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Trifluoromethoxy)benzyl bromide(159689-88-0)
• EPA Substance Registry System: 3-(Trifluoromethoxy)benzyl bromide(159689-88-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 159689-88-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

3-(Bromomethyl)trifluoromethoxybenzene is a reagent used in the preparation of aminophosphorylalkanoic acid derivatives as aminopeptidase A inhibitors.

General Description

3-(Trifluoromethoxy)benzyl bromide undergoes the Friedel-Crafts polymerization in the presence of aluminum chloride catalyst to afford the polymer.

InChI:InChI=1/C8H4BrF3O2/c9-7(13)5-2-1-3-6(4-5)14-8(10,11)12/h1-4H/p+1

Upstream product

• 203302-97-0 2-(3-(trifluoromethoxy)phenyl)acetic acid 

Downstream Products

• 915700-88-8 1-(3-trifluoromethoxy-benzyl)-1H-indole-2-carboxylic acid ethyl ester 
• 1026790-81-7 3(R)-3-{[(1-phenylcycloheptyl)carbonyl]oxy}-1-[3-(trifluoromethoxy)benzyl]-1-azoniabicyclo[2.2.2]octane bromide 
• 1035456-05-3 8-(3-trifluoromethoxybenzyl)-6-(2-methylphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1049806-16-7 methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate 
• 942432-08-8 methyl {6-chloro-2,5-dimethyl-1-[3-(trifluoromethoxy)benzyl]-1H-indol-3-yl}acetate 
• 1270046-01-9 4-(1H-imidazol-1-ylmethyl)-7-{[3-(trifluoromethoxy)benzyl]oxy}-2H-chromen-2-one 
• 1270046-43-9 4-(chloromethyl)-7-{[3-(trifluoromethoxy)benzyl]oxy}-2H-chromen-2-one 
• 1338825-93-6 2-ethyl-8-(hydroxymethyl)-7-((3-trifluoromethoxy)benzyloxy)-4H-chromen-4-one 
• 1311412-04-0 C₃₁H₄₃BrF₃NO₆Si 
• 1416975-90-0 C₂₅H₂₉BrF₃NO₆ 
• 1416976-30-1 C₃₅H₃₅ClF₃N₃O₆ 
• 1416976-11-8 C₄₀H₄₃ClF₃N₃O₈ 
• 1311409-83-2 C₄₃H₄₈ClF₃N₄O₉ 
• 1416975-93-3 C₃₄H₃₇BrClF₃N₂O₇ 

Relevant articles and documents

Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids

The silver-catalyzed Hunsdiecker bromination of aliphatic carboxylic acids is described. With Ag(Phen)2OTf as the catalyst and dibromoisocyanuric acid as the brominating agent, various aliphatic carboxylic acids underwent decarboxylative bromination to provide the corresponding alkyl bromides under mild conditions. This method not only is efficient and general but also enjoys wide functional group compatibility. An oxidative radical mechanism involving Ag(II) intermediates is proposed.