15971-88-7Relevant academic research and scientific papers
Benzene Alkylation with Cycloolefins under the Action of [Et3NH]+[Al2Cl7]? Ionic Liquid
Aminov,Mazitova,Khusnutdinov
, p. 2171 - 2177 (2020/01/08)
Benzene alkylation with mono- and bicyclic olefins under the action of an inorganic ionic liquid [Et3NH]+[Al2Cl7]? with the formation of benzene cycloalkyl derivatives in 58–98% yield has been performed for the first time. It has been found that the increase in the olefin cycle size improves the selectivity with respect to monocycloalkyl derivatives.
Redox-Active Esters in Fe-Catalyzed C-C Coupling
Toriyama, Fumihiko,Cornella, Josep,Wimmer, Laurin,Chen, Tie-Gen,Dixon, Darryl D.,Creech, Gardner,Baran, Phil S.
, p. 11132 - 11135 (2016/10/12)
Cross-couplings of alkyl halides and organometallic species based on single electron transfer using Ni and Fe catalyst systems have been studied extensively, and separately, for decades. Here we demonstrate the first couplings of redox-active esters (both isolated and derived in situ from carboxylic acids) with organozinc and organomagnesium species using an Fe-based catalyst system originally developed for alkyl halides. This work is placed in context by showing a direct comparison with a Ni catalyst for >40 examples spanning a range of primary, secondary, and tertiary substrates. This new C-C coupling is scalable and sustainable, and it exhibits a number of clear advantages in several cases over its Ni-based counterpart.
An efficient method for aromatic Friedel-Crafts alkylation, acylation, benzoylation, and sulfonylation reactions
Singh, Ravi P,Kamble, Rajesh M,Chandra, Kusum L,Saravanan,Singh, Vinod K
, p. 241 - 247 (2007/10/03)
Aromatic electrophilic substitution reactions such as alkylation, acylation, benzoylation, and sulfonylation were studied in the presence of a catalytic amount of Cu(OTf)2 and Sn(OTf)2. Cu(OTf)2 was very efficient for alkylation, acylation, and benzoylation reactions. However, in case of sulfonylation reactions, Sn(OTf)2 gave better results.
Hydrocarbon activation. Synthesis of β-cycloalkyl (Di)nitriles through photosensitized conjugate radical addition
Cardarelli,Fagnoni,Mella,Albini
, p. 7320 - 7327 (2007/10/03)
Photoinduced hydrogen abstraction from aliphatic cyclic hydrocarbons (C5 to C7, C12, as well as adamantane) by triplet aromatic ketones in the presence of α,β-unsaturated (di)nitriles offers a straightforward entry to the corresponding alkylated (di)nitriles via the alkyl radicals. Yields are moderate to good depending on the olefins structure (substitution in β slows down the addition to mononitriles, but with α,α-dinitriles electronic activation allows efficient alkylation also of β,β-disubstituted substrates). A tandem alkylation - cyclization process has been obtained with (1-methylpent-4-enylidene)malononitrile.
