159722-58-4

Basic information

• Product Name: Benzenepropanamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)--alpha--ethyl-
• Synonyms: Benzenepropanamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)--alpha--ethyl-
• CAS NO: 159722-58-4
• Molecular Formula: C21H30N4O3
• Molecular Weight: 386.49
• Mol File: 159722-58-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenepropanamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)--alpha--ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)--alpha--ethyl-(159722-58-4)
• EPA Substance Registry System: Benzenepropanamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)--alpha--ethyl-(159722-58-4)

Safety Data

• Hazardous Substances Data: 159722-58-4(Hazardous Substances Data)

Upstream product

• 81250-34-2 1,3-dipropyl-5,6-diaminouracil 
• 56640-46-1 1-(phenylmethyl)butanoic acid 

Relevant articles and documents

Xanthines with C8 chiral substituents as potent and selective adenosine A1 antagonists.

Several 8-substituted 1,3-dipropylxanthines were synthesized, and their receptor binding affinities at adenosine A1 and A2 receptors were measured. When enantiomeric pairs of compounds were examined, the R enantiomers were significantly more potent than the corresponding S enantiomers. The most potent compound at the A1 receptor was (R)-3,7-dihydro-8-(1-methyl-2-phenylethyl)-1,3-dipropyl-1H-purine-2,6-di one (5a; MDL 102,503), whose Ki value at the A1 receptor was 6.9 nM. However, a more selective compound was (R)-3,7-dihydro-8-(1-phenylpropyl)-1,3-dipropyl-1H-purine-2,6-dione (5d; MDL 102,234), which had a Ki value of 23.2 nM at the A1 receptor and an A2/A1 ratio of 153.