159730-65-1

Upstream product

• 90921-71-4 4-(dimethoxymethyl)benzonitrile 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 1221440-44-3 C₂₂H₂₄N₂O₅ 
• 1370343-64-8 C₃₆H₅₆N₆O₆ 

Relevant academic research and scientific papers

Degradable hybrid materials based on cationic acylhydrazone dynamic covalent polymers promote dna complexation through multivalent interactions

The design of smart nonviral vectors for gene delivery is of prime importance for the successful implementation of gene therapies. In particular, degradable analogues of macromolecules represent promising targets as they would combine the multivalent pres

FLUORESCENT PROBE FOR ALDH3A1 DETECTION

[Problem to be Solved] To provide a fluorescent probe for ALDH3A1 detection that can be used in flow cytometry adaptable to live cells. [Means of Resolution] A compound represented by general formula (I) or a salt thereof, wherein the compound or salt the

Site-specific traceless coupling of potent cytotoxic drugs to recombinant antibodies for pharmacodelivery

Aldehyde drugs are gaining increasing research interest, considering that aldehyde dehydrogenases overexpression is characteristic of cancer stem cells. Here, we describe the traceless site-specific coupling of a novel potent drug, containing an aldehyde

Dynamic combinatorial chemistry with hydrazones: Libraries incorporating heterocyclic and steroidal motifs

We expand the possibilities in hydrazone based dynamic combinatorial chemistry with a series of new building blocks incorporating heterocyclic motifs. The synthetic procedure allows efficient access to building blocks with the general structure (MeO)2CH-Heterocycle-C(O)NHNH2, originating from heterocycles with an amine and an ester functionality. The equilibrium distribution of macrocyclic N-acyl hydrazones formed upon deprotection of the building blocks with TFA in organic solvents is reported. The mixing behaviour of these heterocycle-based building blocks with our cholate-based building blocks is described, particularly the observation of kinetic intermediates that disappear following 'proof-reading'. The Royal Society of Chemistry.

New and efficient arrays for photoinduced charge separation based on perylene bisimide and corroles

The bichromophoric systems C2-PI, C3-PI, and C3-PPI consisiting of corrole and perylene bisimide units and representing one of the rare cases of elaborate structures based on corrole, have been synthesized. Corroles C2 and C3 are, respectively, meso-substituted corroles with 2,6-dichlorophenyl and pentafluorophenyl substituents at the 5 and 15 positions. The three dyads were prepared by divergent strategy with the corrole-forming reaction as the last step of the sequence. C2-PI and C3-PI differ in the nature of the corroles, whereas C3-PI differs from C3-PPI in the presence of a further phenyl unit in the linker between photoactive units. The dyads display spectroscopic properties which are the superposition of the component spectra, indicating a very weak electronic coupling. Excitation of the corrole unit leads to charge separation with a rate which decreases from 2.4 × 1010, to 5.0 × 109, and to 4.9 × 107 s-1 for C2-PI, C3-PI, and C3-PPI, respectively, where the reaction is characterized by a ΔG° > 0. Excitation of the perylene bisimide unit is followed by competing reactions of; 1) energy transfer to the corrole unit, which subsequently deactivates to the charge-separated state and; 2) electron transfer to directly form the charge-separated state. The ratio of electron-to-energy- transfer rates is 9;1 and 1;1 for C3-PI and C3-PPI, respectively. The yield of charge separation is essentially 100% for C2-PI and C3-PI, and approximately 50% (excitation of peryleneimide) or 15% (excitation of the corrole) for C3-PPI. The lifetime of the charge-separated state, observed for the first time in corrole-based structures, is 540 ps for C2-PI, 2.5 ns for C3-PI, and 24 ns for C3-PPI, respectively. This is in agreement with an inverted behavior, according to Marcus theory.

The fluorescence labelling of primary amines with perylenetetracarboxdiimides

The synthesis of perylenetetracarboxdiimide-labelled aldehydes is described as well as their condensation with primary amines. Thus, a highly fluorescent and light-fast fluorescence labelling process has been demonstrated. Application of this method to bi