159730-67-3

Upstream product

• 501-53-1 benzyl chloroformate 
• 39895-56-2 4-hydroxymethyl-benzylamine 
• 1020415-08-0 (4-((((benzyloxy)carbonyl)amino)methyl)phenyl)methanol 
• 1075221-26-9 benzyl [4-(1,3-dioxolan-2-yl)benzyl]carbamate 
• 63914-51-2 [(4-cyanophenyl)methyl]-carbamic acid phenylmethyl ester 

Downstream Products

• 1075221-28-1 C₂₄H₂₄N₂O₃ 
• 1608150-71-5 tert-butyl ((S)-1-(((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-7-(2-((4-((((benzyloxy)carbonyl)amino)methyl)benzyl)(tert-butoxycarbonyl)amino)ethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-6-yl)amino)-1-oxobutan-2-yl)(methyl)carbamate 
• 1608150-72-6 tert-butyl ((S)-1-(((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-7-(2-((4-((((benzyloxy)carbonyl)amino)methyl)benzyl)(tert-butoxycarbonyl)amino)ethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-6-yl)amino)-1-oxobutan-2-yl)(methyl)carbamate 
• 1608150-73-7 4-((4-(((2-((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-6-((S)-2-((tertbutoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-7-yl)ethyl)(tert-butoxycarbonyl)amino)methyl)benzyl)amino)-4-oxobutanoic acid 
• 1608150-70-4 tert-butyl ((S)-1-(((3S,6S,7R,9aS)-3-(benzhydrylcarbamoyl)-7-(2-((4-((((benzyloxy)carbonyl)amino)methyl)benzyl)amino)ethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepin-6-yl)amino)-1-oxobutan-2-yl)(methyl)carbamate 

Relevant academic research and scientific papers

Photoswitchable sensitization of porphyrin excited states

Light-driven molecular switches consisting of a porphyrin covalently linked to a fulgimide photochrome antenna have been prepared. Light absorbed by the cyclic form of the fulgimide is transferred to the porphyrin with ? 95% efficiency, generating the por

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αvβ3/α vβ5 integrins and IAP proteins

The rational design, synthesis and in vitro biological evaluation of dual action conjugates 11-13, containing a tumour targeting, integrin αvβ3/αvβ5 ligand portion and a pro-apoptotic SMAC mimetic portion (cyclo-RGD/SMAC mimetic conjugates) are reported. The binding strength of the two separate units is generally maintained by these dual action conjugates. In particular, the connection between the separate units (anchor points on each unit; nature, length and stability of the linker) influences the activity of each portion against its molecular targets (integrins αvβ3/ αvβ5 for cyclo-RGD, IAP proteins for SMAC mimetics). Each conjugate portion tolerates different substitutions while preserving the binding affinity for each target.

Synthesis of α,α-difluoro-β-amino esters or gem-difluoro-β-lactams as potential metallocarboxypeptidase inhibitors

The synthesis of gem-difluorinated β-lactams and gem-difluorinated β-amino acids, each possessing a potential basic functional group, from ethyl bromodifluoroacetate and either imines (for β-lactams) or N-(α-aminoalkyl)benzotriazoles (for β-amino esters) was investigated. A series of these compounds were used for the design of novel metallocarboxypeptidase inhibitors. N-Alkylation and N-acylation of these two versatile scaffolds were carried out, leading to the expected targets in moderate to good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.