159734-82-4Relevant academic research and scientific papers
A New Synthesis of Highly Functional Nitrones through a Nitrosoketene Intermediate and Their Use for the Stereoselective Synthesis of Amino Acids
Katagiri, Nobuya,Sato, Hiroshi,Kurimoto, Ayumu,Okada, Makoto,Yamada, Akemi,Kaneko, Chikara
, p. 8101 - 8106 (2007/10/02)
Reaction of 5-isonitroso-2,2-dimethyl-1,3-dioxane-4,6-dione with various ketones under reflux in toluene gives 3-oxazolin-5-one 3-oxides (cyclic nitrones) via a nitrosoketene intermediate generated from the isonitroso derivative.The cyclic nitrones can be used for the stereoselective dipolar cycloaddition to electron-rich olefins under high pressure to produce fused isoxazolidines.These isoxazolidines, in turn, are versatile intermediates for the stereoselective preparation of substituted α-amino acids.
