1597408-49-5

Basic information

• Product Name: (E)-2-bromo-1-[2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one
• Synonyms: (E)-2-bromo-1-[2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one
• CAS NO: 1597408-49-5
• Molecular Weight: 539.406
• Mol File: 1597408-49-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-2-bromo-1-[2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-bromo-1-[2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one(1597408-49-5)
• EPA Substance Registry System: (E)-2-bromo-1-[2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one(1597408-49-5)

Safety Data

• Hazardous Substances Data: 1597408-49-5(Hazardous Substances Data)

Upstream product

• 172877-90-6 1-[2-(bromomethyl)-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one 
• 172877-89-3 1-[2-methyl-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one 
• 552-89-6 2-nitro-benzaldehyde 
• 80360-21-0 1-(benzenesulfonyl)-2-methyl-1H-indole 
• 4106-18-7 1-(phenylsulfonyl)-1H-benzo[d][1,2,3]triazole 
• 95-20-5 2-methyl-1H-indole 
• 1597408-43-9 (E)-1-[2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one 

Downstream Products

• 1597408-84-8 3-(bromomethyl)-4-methoxy-2-(2-nitrophenyl)-9-(phenylsulfonyl)-9H-carbazole 
• 1597408-89-3 4-methoxy-2-(2-nitrophenyl)-9-(phenylsulfonyl)-9H-carbazole-3-carbaldehyde 
• 1597408-76-8 7-methoxy-12-(phenylsulfonyl)-12H-indolo[3,2-j]phenanthridine 
• 1597408-32-6 4-methoxy-3-methyl-2-(2-nitrophenyl)-9-(phenylsulfonyl)-9H-carbazole 
• 1445973-98-7 4-hydroxy-2-(2-nitrophenyl)-9-(phenylsulfonyl)-9H-carbazole-3-carbaldehyde 
• 863498-12-8 4-hydroxy-2-(2-nitrophenyl)-9H-carbazole-3-carbaldehyde 
• 1597408-95-1 12-(phenylsulfonyl)-12H-indolo[3,2-j]phenanthridin-7-ol 
• 1597408-58-6 (E)-1-[2-(2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one 

Relevant articles and documents

Total synthesis of calothrixin B and its analogs

The total synthesis of calothrixin B and its analogs was achieved starting from 2-methylindole. The synthesis involved an electrocyclization of 2-nitroarylvinyl-3-phenylsulfonylvinylindoles as a key step to give 2-nitroaryl-4-methoxy-3-methylcarbazoles. Oxidation of these compounds followed by reductive cyclization led to N-phenylsulfonylquinocarbazoles. These quinocarbazoles underwent hydrolysis and aerial oxidation in one pot to give the target compounds. A linear synthesis of calothrixin B and its analogs has been established from commercially available 2-methylindole. The thermal electrocyclization of 2-nitroarylvinyl-3-phenylsulfonylindole was a key step in the synthesis. The synthesis of calothrixin B and its analogs was achieved in 12-22 % overall yield over twelve steps. Copyright