1597415-35-4Relevant academic research and scientific papers
Pseudopeptidic compounds for the generation of dynamic combinatorial libraries of chemically diverse macrocycles in aqueous media
Atcher, Joan,Solà, Jordi,Alfonso, Ignacio
supporting information, p. 213 - 219 (2016/12/27)
A straightforward four-step synthesis leads to the preparation of C2-symmetric dithiols containing a central aromatic core and amino acid side chains. These building blocks allow the preparation of dynamic covalent libraries of pseudopeptidic macrocycles in aqueous media that cover a broad range of polarities, functional groups and bulkiness mirroring the diversity found in natural peptides. The versatility of the generated dynamic libraries has been illustrated by the amplification of two different members from the same library upon the action of two biologically relevant templates.
Constitutional self-selection from dynamic combinatorial libraries in aqueous solution through supramolecular interactions
Sola, Jordi,Lafuente, Maria,Atcher, Joan,Alfonso, Ignacio
supporting information, p. 4564 - 4566 (2014/05/06)
We describe the predominant formation of a specific constitution arising from the combination of building blocks with different topologies through disulphide chemistry in a Dynamic Combinatorial Library (DCL). The supramolecular interactions established by a zwitterionic cysteine moiety are responsible for the self-selection of one product from all the virtual members of a large library. the Partner Organisations 2014.
