1597443-58-7Relevant academic research and scientific papers
Discovery of a neuroprotective chemical, (S)- N -(3-(3,6-Dibromo-9 H -carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties
Naidoo, Jacinth,De Jesus-Cortes, Hector,Huntington, Paula,Estill, Sandi,Morlock, Lorraine K.,Starwalt, Ruth,Mangano, Thomas J.,Williams, Noelle S.,Pieper, Andrew A.,Ready, Joseph M.
, p. 3746 - 3754 (2014)
(-)-P7C3-S243 is a neuroprotective aminopropyl carbazole with improved druglike properties compared with previously reported compounds in the P7C3 class. It protects developing neurons in a mouse model of hippocampal neurogenesis and protects mature neurons within the substantia nigra in a mouse model of Parkinsons disease. A short, enantioselective synthesis provides the neuroprotective agent in optically pure form. It is nontoxic, orally bioavailable, metabolically stable, and able to cross the blood-brain barrier. As such, it represents a valuable lead compound for the development of drugs to treat neurodegenerative diseases and traumatic brain injury.
