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Upstream product

• 425-61-6 2,2,3,3-tetrafluorobutane-1,4-diol 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 1437796-88-7 3,3,4,4-tetrafluoro-1-(4-iodophenyl)pyrrolidine 
• 1415593-51-9 4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)benzenamine 

Relevant academic research and scientific papers

Aggregation-induced emission based on a fluorinated macrocycle: visualizing spontaneous and ultrafast solid-state molecular motions at room temperature: via F?F interactions

We for the first time report the efficient construction of novel tetraphenethylene (TPE)-based macrocycles with various mechanofluorochromism (MFC) behaviors involving solid-state molecular motions. We were able to facilely regulate the diverse solid-stat

3,4-Difluoropyrrole-, 3,3,4,4-tetrafluoropyrrolidine- and pyrrolidine-based liquid crystals

A new class of liquid crystals was formed with N-heterocycles as the terminal group, such groups as a 3,4-difluoropyrrole, 3,3,4,4- tetrafluoropyrrolidine, or pyrrolidine. Their properties were modified by varying the terminal heterocycles and/or the leng

Fluorocarbon and hydrocarbon benzodioxocycloalkane (C8-C 10) end groups: Effects on mesomorphism

A new class of benzodioxocycloalkane-based (C8-C10) liquid crystals were prepared. The impact of ring (C8-C10) as end group was investigated. The 8-9 membered ring derivatives, 3a-3b, exhibited the nematic phases (N). The mesomorphic behaviors were weakened with increasing the size of the ring. For the ?uorinated medium ring (C 8-C10) 3d-3f, it was found only the fluorinated ten membered ring 3f showed the LC phases behaviours. Modification of the ring size with different length alkyl groups and variation of the alkyl to polyfluoroalkyl markedly influenced the properties of these compounds. A new class of benzodioxocycloalkane-based (C8-C10) liquid crystals has been prepared. The impact of ring (C8-C10) as end group was investigated. The 8-9 membered ring derivatives, 3a-3b, exhibited the nematic phases (N). The mesomorphic behaviors were weakened with increasing the size of the ring. For the ?uorinated medium ring (C8-C10) 3d-3f, it was found only the fluorinated ten membered ring 3f showed the LC phases behaviours. Modification of the ring size with different length alkyl groups and variation of the alkyl to polyfluoroalkyl markedly influenced the properties of these compounds. Copyright

PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES

The present invention relates to a class of TrkA inhibitors and an application thereof in the preparation of a drug for the treatment of diseases associated with TrkA. The present invention specifically discloses compounds represented by formula (I) and f

Tetrastyrene macrocyclic compound with force-induced fluorescence color-changing performance and synthesis method and application thereof

The invention discloses a tetrastyrene macrocyclic compound with force-induced fluorescence color changing performance. The compound is connected with an alkyl chain structural unit through the strongfluorescence property of the tetrastyrene macrocyclic c

Fluorocarbon and hydrocarbon N-heterocyclic (C5-C7) difluorooxymethylene-bridged liquid crystals

A series of new fluorocarbon and hydrocarbon N-heterocyclic (C 5-C7) difluorooxymethylene-bridged liquid crystals have been prepared. The impact of ring (C5-C7) as end group was investigated. Compounds with term

3,4-Difluoropyrrole-, 3,3,4,4-tetrafluoropyrrolidine-based tolan liquid crystals

A series of new 3,4-difluoropyrrole-, 3,3,4,4-tetrafluoropyrrolidine-based tolan liquid crystals resulted from palladium-free Sonogashira coupling reactions of 1-(4-iodophenyl)-3,4-difluoropyrrole, 1-(4-iodophenyl)-3,3,4,4- tetrafluoropyrrolidine with terminal phenyl acetylenes. These new compounds exhibit typical nematic and smectic phases, good thermal stabilities, and high clearing points in comparison to the liquid crystal phase of 3,4-difluorobenzene-based tolan. These encouraging results lead us to believe this class of compounds could be used as new liquid crystalline materials. It is possible that the fluorinated N-heterocycles, 3,4-difluoropyrrole and 3,3,4,4-tetrafluoropyrrolidine, could replace the expensive 2,3-difluorobenzene, 3,4-difluorobenzene, and 3,4,5-trifluorobenzene components in the tolan core structure to form promising liquid crystalline materials.

Pyridinium-based ionic liquid crystals with terminal fluorinated pyrrolidine

A new class pyridinium-based liquid crystals with an extended fluorinated pyrrolidine were synthesized. These compounds show a wide mesophase range and are stable to high temperatures after an introduction of a fluorinated pyrrolidine to the terminal end.

2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST

The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the thrombin PAR-1 receptor antagonists.

METHOD FOR PRODUCING TETRAFLUORO COMPOUND

Provided is a method for producing a tetrafluoro nitrogen-containing heterocyclic compound such as tetrafluoropyrrolidine in good yield and at low cost. The method comprises the steps of: (A) reacting a compound represented by the formula (I) with fluorine gas to produce a tetrafluoro compound represented by the formula (II), (B) converting the tetrafluoro derivative represented by the formula (II) to a compound represented by the formula (III), and (C) reacting the compound represented by the formula (III) with an amine compound represented by the formula NH2R9 to produce a tetrafluoro nitrogen-containing heterocyclic compound represented by the formula (IV) or salt thereof.