159770-26-0Relevant academic research and scientific papers
ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS
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Page/Page column 115, (2009/07/17)
The present invention relates to novel compounds of formula (I) capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.
1,3-Dipolar cycloaddition route to nitrogen heterocyclic triones
Jones, Raymond C. F.,Bhalay, Gurdip,Carter, Paul A.,Duller, Kathryn A. M.,Dunn, Stephen H.
, p. 765 - 776 (2007/10/03)
1,3-Dipolar cycloaddition of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ- or δ-amino-β-keto esters affords isoxazole-4-carboxylates; these undergo lactam formation and N-O bond cleavage to afford 3-acyltetramic acids and 3-acyl-4-hydroxypyridin-2-ones.
A Thermal Wolf Rearrangement-Benzannulation Route to Naphthisoxazoles, Benzofuro- or isoxazoles and 1,2-Benzisoxazoles
Chen, Ya Ping,Chantegrel, Bernard,Deshayes, Christian
, p. 175 - 186 (2007/10/02)
The title compounds substituted in position 4 by a dimethylphosphono group and in position 5 by a hydroxy group were prepared by the thermal decomposition of dimethyl 2-(5-aryl-(or furyl or alkenyl)-3-methylisoxazol-4-yl)-2-oxo-1-diazoethylphosphonates th
A cycloaddition Approach to 3-Acyltetramic and 3-Acyltetronic Acids
Jones, Raymond C. F.,Bhalay, Gurdip,Carter, Paul A.,Duller, Kathryn A. M.,Vulto, Simone I. E.
, p. 2513 - 2516 (2007/10/02)
1,3-Dipolar cycloaddition of nitrile oxides to enamines formed from protected γ-amino- or γ-hydroxy-β-keto esters affords isoxazolecarboxylic esters that can be converted into 3-acyltetramic acids via dihydropyrroloisoxazol-4-ones, or into 3-acyltetronic
