159780-24-2

Upstream product

• 33707-21-0 dimethyl <3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenylidene>malonate 
• 2393-23-9 4-methoxy-benzylamine 
• 174740-67-1 dimethyl <2-(ethoxycarbonyl)ethylidene>malonate 
• 617-35-6 2-oxo-propionic acid ethyl ester 

Downstream Products

• 1026366-16-4 [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-(2-naphthalen-1-yl-ethylcarbamoyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester 
• 1027302-51-7 {1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-[(naphthalen-1-ylmethyl)-carbamoyl]-2-oxo-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester 
• 159780-51-5 2-[3-Benzyloxycarbonylamino-4-(4-methoxybenzylaminocarbonyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 1026172-90-6 [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-4-(2-oxo-2-phenyl-ethylcarbamoyl)-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester 
• 1026170-60-4 [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-(1,1-dimethyl-2-phenyl-ethylcarbamoyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester 
• 1025955-79-6 (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-4-phenethylcarbamoyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester 
• 1026415-73-5 (4-Benzylcarbamoyl-1-{[2-(tert-butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester 
• 159780-36-6 (7-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2,4,8-trioxo-1,4,7,8-tetrahydro-2H-pyrido[3,4-d]pyrimidin-3-yl)-acetic acid benzyl ester 
• 159780-17-3 2-(3-Benzyloxycarbonylamino-4-ethoxycarbonyl-2-oxo-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-52-6 2-[3-(4-Methoxybenzyl)-2,4,8-trioxo-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159779-97-2 {2,4,8-Trioxo-7-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,4,7,8-tetrahydro-2H-pyrido[3,4-d]pyrimidin-3-yl}-acetic acid benzyl ester 
• 159780-32-2 N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[2,4,8-trioxo-3-(2-oxo-2-phenyl-ethyl)-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide 
• 1025801-00-6 (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-methylcarbamoyl-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester 
• 159780-33-3 N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(1,1-dimethyl-2-phenyl-ethyl)-2,4,8-trioxo-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide 

Relevant academic research and scientific papers

Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones

Using molecular modeling and the information derived from X-ray crystal structures of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonpeptidic inhibitors of HNE, the