159780-69-5Relevant academic research and scientific papers
Certain isoquinoline derivatives having anti-tumor properties
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, (2008/06/13)
Compounds are described of general formula (I) STR1 and salts and solvates thereof, including physiologically acceptable salts and solvates thereof, in which: Z represents either Het, STR2 Het represents an optionally substituted bicyclic or tricyclic ring selected from acricine isoquinolin-1-yl, isoquinolin-3-yl, The novel compounds of formula (I) can sensitize multi-drug resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an anti-tumour drug.
