159783-16-1

Usage

Uses

Used in Pharmaceutical Research:
3-(Cyclopentyloxy)-4-methoxybenzonitrile is used as a key intermediate in the synthesis of various types of drugs and biologically active molecules. Its unique structure and properties contribute to the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Research:
In the agrochemical industry, 3-(Cyclopentyloxy)-4-methoxybenzonitrile serves as a valuable intermediate for the development of new agrochemicals. Its chemical properties allow for the creation of compounds with potential applications in crop protection, pest control, and other agricultural areas.
Used in Organic Synthesis:
3-(Cyclopentyloxy)-4-methoxybenzonitrile is used as a building block in the synthesis of more complex chemical structures. Its versatility and reactivity make it an essential component in the creation of advanced organic compounds for various applications, including materials science, specialty chemicals, and more.

InChI:InChI=1/C13H15NO2/c1-15-12-7-6-10(9-14)8-13(12)16-11-4-2-3-5-11/h6-8,11H,2-5H2,1H3

Upstream product

• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 52805-46-6 2-methoxy-5-cyanophenol 
• 621-59-0 isovanillin 

Downstream Products

• 874485-04-8 C₁₃H₁₈N₂O₃ 
• 883013-26-1 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole 
• 1163715-94-3 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole 
• 883013-59-0 5-(4-chlorophenyl)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-1,2,4-oxadiazole 
• 1163715-95-4 4-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)phenol 
• 1163715-96-5 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(pyridin-4-yl)-1,2,4-oxadiazole 
• 1163715-97-6 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole 
• 1163715-98-7 5-((1H-indol-3-yl)methyl)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-1,2,4-oxadiazole 
• 1163715-99-8 1-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)propan-2-one 
• 1312793-96-6 ethyl 4-(3-(3-cyclopentyloxy-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate 
• 1312793-89-7 3-(3-cyclopentyloxy-4-methoxyphenyl)-5-(trichloromethyl)-1,2,4-oxadiazole 
• 1312793-83-1 5-cyclopentyl-3-(3-cyclopentyloxy-4-methoxy-phenyl)-1,2,4-oxadiazole 
• 1312793-82-0 5-cyclohexyl-3-(3-cyclopentyloxy-4-methoxyphenyl)-1,2,4-oxadiazole 
• 1312793-91-1 3-(3-cyclopentyloxy-4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Design and Synthesis of 3,5-Disubstituted-1,2,4-Oxadiazoles as Potent Inhibitors of Phosphodiesterase4B2

A series of 3,5-disubstituted-1,2,4-oxadiazoles has been prepared and evaluated for phosphodiesterase inhibition (PDE4B2). Among the prepared 3,5-disubstituted-1,2,4-oxadiazoles, compound 9a is the most potent inhibitor (PDE4B2 IC50=5.28μm). Structure-activity relationship studies of 3,5-disubstituted-1,2,4-oxadiazoles revealed that substituents 3-cyclopentyloxy-4-methoxyphenyl group at 3-position and cyclic ring bearing heteroatoms at 5-position are important for activity. Molecular modeling study of the 3,5-disubstituted-1,2,4-oxadiazoles with PDE4B has shown similar interactions of 3-cyclopentyloxy-4-methoxyphenyl group; however, heteroatom ring is slightly deviating when compared to Piclamilast. 3-(3-Cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole (9a) exhibited good analgesic and antiinflammatory activities in formalin-induced pain in mice and carrageenan-induced paw edema model in rat.

6-phenyltetrahydro-1,3-oxazin-2-one derivative and pharmaceutical composition containing the same

A 6-phenyltetrahydro-1,3-oxazin-2-one derivative having the formula (I): wherein, R1is an unsubstituted or substituted C1to C8alkyl group; an unsubstituted or substituted C3to C7cycloalkyl group;, etc

COMPOUNDS CONTAINING PHENYL LINKED TO ARYL OR HETEROARYL BY AN ALIPHATIC- OR HETEROATOM-CONTAINING LINKING GROUP

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.