159783-22-9

Basic information

• Product Name: 4-Amino-3,5-difluoropyridine
• Synonyms: 4-Pyridinamine,3,5-difluoro-(9CI);3,5-Difluoropyridin-4-amine
• CAS NO: 159783-22-9
• Molecular Formula: C₅H₄F₂N₂
• Molecular Weight: 130.09
• Product Categories: AMINEPRIMARY;PYRIDINE
• Mol File: 159783-22-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 175 °C at 760 mmHg
• Flash Point: 59.6 °C
• Appearance: /
• Density: 1.393 g/cm³
• Vapor Pressure: 1.17mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.12±0.24(Predicted)
• CAS DataBase Reference: 4-Amino-3,5-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3,5-difluoropyridine(159783-22-9)
• EPA Substance Registry System: 4-Amino-3,5-difluoropyridine(159783-22-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 159783-22-9(Hazardous Substances Data)

Usage

General Description

4-Amino-3,5-difluoropyridine is a chemical compound with the molecular formula C5H4F2N2. It is a heterocyclic organic compound that belongs to the pyridine family. This chemical is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its important role in the development of various drugs and active pharmaceutical ingredients. 4-Amino-3,5-difluoropyridine is also used as a building block in the production of various heterocyclic compounds and is valued for its potential application in the fields of medicinal chemistry and chemical research. Due to its unique structure and properties, it is widely utilized in the pharmaceutical and agrochemical industries for the development of new and effective products.

InChI:InChI=1/C5H4F2N2/c6-3-1-9-2-4(7)5(3)8/h1-2H,(H2,8,9)

Upstream product

• 105252-95-7 2,3,5-trifluoropyridin-4-amine 

Downstream Products

• 171803-98-8 N-(3,5-difluoropyrid-4-yl)-4-(methylthio)-3-(tetrahydro-furan-3-yloxy)benzamide 
• 1253113-01-7 N-(3,5-difluoro-4-pyridinyl)-1-([2-(phenyloxy)phenyl]methyl)-1H-pyrazole-3-carboxamide 
• 1253113-05-1 1-([2-(butyloxy)phenyl]methyl)-N-(3,5-difluoro-4-pyridinyl)-1H-pyrazole-3-carboxamide 
• 1616930-17-6 4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide 
• 1365992-64-8 2,6-dichloro-4-cyano-N-(3,5-difluoropyridin-4-yl)-benzamide 
• 1365992-92-2 2-fluoro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide 
• 1365992-93-3 C₁₉H₈F₄N₄O₆ 
• 1365992-83-1 2-chloro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide 
• 1365992-84-2 2-chloro-N-(2-chloro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide 
• 1365992-55-7 2,6-dichloro-N-(3,5-difluoropyridin-4-yl)-benzamide 
• 1365992-56-8 2,6-dichloro-N-(2,6-dichlorobenzoyl)-N-(3,5-difluoropyridin-4-yl)-benzamide 
• 1365993-00-5 2-(4-bromo-7-fluorothiazolo[5,4-c]pyridin-2-yl)-3-fluorobenzonitrile 
• 1365992-99-9 3-fluoro-2-(4-chloro-7-fluorothiazolo[5,4-c]pyridin-2-yl)-benzonitrile 
• 1365992-98-8 3-fluoro-2-(7-fluoro-5-oxythiazolo[5,4-c]pyridin-2-yl)-benzonitrile 

Relevant articles and documents

COMPOUNDS CONTAINING PHENYL LINKED TO ARYL OR HETEROARYL BY AN ALIPHATIC- OR HETEROATOM-CONTAINING LINKING GROUP

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.