1598-33-0Relevant academic research and scientific papers
Continuous-flow synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines in a C-N bond formation/hydrogenation/ diazotization/cyclization sequence
Chen, Mao,Buchwald, Stephen L.
supporting information, p. 4247 - 4250 (2013/05/08)
Two approaches have been developed for the regiospecific continuous-flow synthesis of 1-substituted benzotriazoles. They begin with either an S NAr reaction at high temperature or Pd catalysis and involve consecutive multiphase processes, allow
A practical oxone - Mediated, high-throughput, solution-phase synthesis of benzimidazoles from 1,2-phenylenediamines and aldehydes and its application to preparative scale synthesis
Beaulieu, Pierre L.,Hache, Bruno,Von Moos, Elisabeth
, p. 1683 - 1692 (2007/10/03)
Addition of oxone to a mixture of a 1,2-phenylenediamine and an aldehyde in wet DMF at room temperature results in rapid formation of benzimidazoles under very mild conditions. The reaction is applicable to a wide range of substrates including aliphatic,
