159831-89-7

Basic information

• Product Name: Pyridine,2-[(fluoromethyl)thio]-(9CI)
• Synonyms: Pyridine,2-[(fluoromethyl)thio]-(9CI)
• CAS NO: 159831-89-7
• Molecular Formula: C6H6FNS
• Molecular Weight: 143.1819432
• Product Categories: PYRIDINE
• Mol File: 159831-89-7.mol

Chemical Properties

• Boiling Point: 210.9±20.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• PKA: 1.99±0.19(Predicted)
• CAS DataBase Reference: Pyridine,2-[(fluoromethyl)thio]-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine,2-[(fluoromethyl)thio]-(9CI)(159831-89-7)
• EPA Substance Registry System: Pyridine,2-[(fluoromethyl)thio]-(9CI)(159831-89-7)

Safety Data

• Hazardous Substances Data: 159831-89-7(Hazardous Substances Data)

Upstream product

• 18438-38-5 2-methylsulfanyl-pyridine 
• 2637-34-5 2-Sulfanylpyridine 
• 593-70-4 R₃₂ 

Downstream Products

• 1365765-53-2 2-((fluoromethyl)sulfonyl)pyridine 

Relevant articles and documents

Electrolytic Partial Fluorination of Organic Compounds. 13. Selective Anodic α-Fluorination of Nitrogen-Containing Heterocyclic Sulfides and Its Application to the Synthesis of Fluorinated Fused Heterocycles

Highly regioselective anodic monofluorination of 2-pyridyl 6-pyrimidinyl sulfides was successfully carried out and fluorinated fused heterocycles were readily prepared in good yields using an anodically fluorinated sulfide.

Direct monofluoromethylation of O-, S-, N-, and P-nucleophiles with PhSO(NTs)CH2F: The accelerating effect of α-fluorine substitution

An efficient and direct monofluoromethylation of O-, S-, N-, and P-nucleophiles with PhSO(NTs)CH2F 1 has been developed. In contrast to the previously known detrimental effect of α-fluorine substitution on SN2 reactions, the current monofluoromethylation is accelerated by the α-fluorine substitution. Based on a mechanistic study, a new reactivity of sulfoximine (as a radical monofluoromethylation reagent) is disclosed.

From olefination to alkylation: In-situ halogenation of julia-kocienski intermediates leading to formal nucleophilic iodo- and bromodifluoromethylation of carbonyl compounds

Iodo- and bromodifluoromethylated compounds are important synthetic intermediates and halogen-bond acceptors. However, direct introduction of -CF2I and -CF2Br groups through nucleophilic addition is particularly challenging because o

Electrolytic partial fluorination of organic compounds. 35. Anodic fluorination of 2-pyrimidyl, 2-pyridyl, and 2-quinazolinonyl sulfides

Highly regioselective electrochemical fluorination of 2-pyrimidyl sulfides having an electron-withdrawing group (EWG) at the position α to the sulfur atom was successfully carried out using Et4NF·nHF (n = 3, 4) or Et3N·3HF as a supporting electrolyte and a fluoride ion source in 1,2- dimethoxyethane (DME) in an undivided cell. 2-Methylthiopyrimidine devoid of an EWG was also selectively fluorinated in DME to provide 2- (fluoromethylthio)pyrimidine in a moderate yield as 63%, while corresponding 2-methylthiopyridine was less selectively fluorinated in lower yield along with α,α-difluorinated product. In contrast, the corresponding 2- quinazolinonyl sulfides underwent similarly α-fluorination along with unexpected ipso-fluorination through anodic desulfurization.

Electrolytic Partial Fluorination of Organic Compounds. 19. A Novel Synthesis of Fluorothienopyridines Using Anodic Fluorination of Heterocyclic Sulfides as a Key Step

Highly regioselective anodic monofluorination of 2-pyridyl and 4-pyrimidinyl sulfides bearing various electron-withdrawing groups were successfully carried out.The fluorinated sulfides were easily converted into 2-fluorothienopyridines in good yields.