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1598426-03-9

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1598426-03-9 Usage

General Description

2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester is a chemical compound with the molecular formula C18H18N4O2. It is an ethyl ester derivative of a pyrimidine carboxylic acid with a phenyl-cyclopropylamino group attached to the pyrimidine ring. 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester has potential pharmaceutical applications, potentially functioning as a drug or drug intermediate. It may also have uses in organic synthesis or as a research tool in the study of pyrimidine derivatives. The specific properties and uses of this compound would need to be further investigated through research and testing.

Check Digit Verification of cas no

The CAS Registry Mumber 1598426-03-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,9,8,4,2 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1598426-03:
(9*1)+(8*5)+(7*9)+(6*8)+(5*4)+(4*2)+(3*6)+(2*0)+(1*3)=209
209 % 10 = 9
So 1598426-03-9 is a valid CAS Registry Number.

1598426-03-9Relevant articles and documents

METALLOENZYME INHIBITOR COMPOUNDS

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Page/Page column 124-125, (2018/09/28)

Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

INCREASING EXPRESSION OF INTERFERON REGULATED GENES WITH COMBINATONS OF HISTONE DEACETYLASE INHIBITORS AND IMMUNOMODULATORY DRUGS

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Page/Page column 53; 54, (2017/09/08)

Provided herein is a combination comprising an HDAC inhibitor and an IMiD for increasing interferon regulated gene expression or decreasing c-MYC gene expression in a cancer cell or tumor in a subject in need thereof. Increasing interferon regulated gene expression may result in increased recognition of tumors by innate or adaptive immune system and an increase in programmed cell death (apoptosis) gene expression, increasing apoptosis in cancer cells and tumors. The cells can be multiple myeloma cells or diffuse large B-cell lymphoma cells. Also provided are methods for treating myelodysplastic syndromes/acute myeloid leukemia (MDS/AML) or pathogen infections in a subject in need thereof comprising administering to the subject an effective amount of HDAC inhibitor and an IMiD. The HDAC inhibitor can be an HDAC6-selective inhibitor.

METHODS OF USE AND PHARMACEUTICAL COMBINATIONS OF HDAC INHIBITORS WITH BET INHIBITORS

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Page/Page column 38; 39, (2018/01/17)

The disclosure relates to pharmaceutical combinations comprising an HDAC6 selective inhibitor and a BET inhibitor for the treatment of cancer in a subject in need thereof. Also provided herein are methods for treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of an HDAC6 selective inhibitor and a BET inhibitor.

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