1598426-36-8

Basic information

• Product Name: 1-(2,6-dichlorophenyl)-3-(6-isopropyl-4-oxo-4H-chromen-3-ylmethylene)-1,3-dihydro-indol-2-one
• Synonyms: 1-(2,6-dichlorophenyl)-3-(6-isopropyl-4-oxo-4H-chromen-3-ylmethylene)-1,3-dihydro-indol-2-one
• CAS NO: 1598426-36-8
• Molecular Weight: 476.359
• Mol File: 1598426-36-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,6-dichlorophenyl)-3-(6-isopropyl-4-oxo-4H-chromen-3-ylmethylene)-1,3-dihydro-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-dichlorophenyl)-3-(6-isopropyl-4-oxo-4H-chromen-3-ylmethylene)-1,3-dihydro-indol-2-one(1598426-36-8)
• EPA Substance Registry System: 1-(2,6-dichlorophenyl)-3-(6-isopropyl-4-oxo-4H-chromen-3-ylmethylene)-1,3-dihydro-indol-2-one(1598426-36-8)

Safety Data

• Hazardous Substances Data: 1598426-36-8(Hazardous Substances Data)

Upstream product

• 49619-58-1 3-formyl-6-isopropylchromone 
• 15362-40-0 1-(2,6-dichlorophenyl)indolin-2-one 

Relevant articles and documents

Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: Identification of a lead for anti-inflammatory drug

Conjugates of chromone-indole and chromone-pyrazole were screened for cyclooxygenase-2 (COX-2), cyclooxygenase-1 (COX-1) and 5-lipoxygenase (5-LOX) inhibitory activities. Compounds 8 and 9 were identified as preferred inhibitors of COX-2 over the other two enzymes. Their IC50 for COX-2 was 29 nM and 20 nM, respectively and selectivity indices (SI) for COX-2 over COX-1 was 46 and 337. NMR, mass spectral studies and molecular modelling also indicated preferential interactions of compounds 8 and 9 with COX-2. Tested on albino mice against capsaicin induced algesia, compound 8 exhibited analgesic potential comparable to diclofenac. In addition to the biological profile, the desirable physico-chemical properties of these compounds make them promising leads for anti-inflammatory drugs.