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15986-31-9

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15986-31-9 Usage

General Description

2-mercaptopurine-6,8-diol is a chemical compound with potential pharmaceutical applications. It is a purine derivative that contains a mercapto group and two hydroxyl groups attached to the purine ring. 2-mercaptopurine-6,8-diol is an analog of the anticancer and immunosuppressive drug mercaptopurine, and it has been studied for its potential use in the treatment of various diseases, including cancer and autoimmune disorders. 2-mercaptopurine-6,8-diol has shown promise in preclinical studies for its ability to inhibit cell growth and to modulate immune responses. Its unique structure and biological activities make it a promising candidate for further development as a potential therapeutic agent.

Check Digit Verification of cas no

The CAS Registry Mumber 15986-31-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,9,8 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 15986-31:
(7*1)+(6*5)+(5*9)+(4*8)+(3*6)+(2*3)+(1*1)=139
139 % 10 = 9
So 15986-31-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N4O2S/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

15986-31-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-sulfanylidene-7,9-dihydro-3H-purine-6,8-dione

1.2 Other means of identification

Product number -
Other names 2-Thio-harnsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15986-31-9 SDS

15986-31-9Relevant articles and documents

Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase

Biagi, Giuliana,Costantini, Alberto,Costantino, Luca,Giorgi, Irene,Livi, Oreste,Pecorari, Piergiorgio,Rinaldi, Marcella,Scartoni, Valerio

, p. 2529 - 2535 (2007/10/03)

Several derivatives of 4,5-disubstituted imidazole, 2,4,5-trisubstituted pyrimidine, 2-substituted purine, thiazolo[3,2-a]purine, [1,3]thiazino[3,2- a]purine, thiazolo[2,3-i]purine, [1,3]thiazino-[2,3-i]purine, and 6- substituted pyrazolo[3,4-d]pyrimidine were synthesized and tested as inhibitors of the xanthine oxidase enzyme. Of those, some 4-(acylamino)-5- carbamoylimidazoles and 2-thioalkyl-substituted purines exhibited very good inhibitory activity, being at least 500 times more effective than allopurinol. The ineffectiveness of 6-n-alkylpyrazolo[3,4-d]pyrimidines is imputable to the alkyl chain which could hinder the coordination with molybdenum according to the known mechanism for the binding of the inhibitor allopurinol; the effectiveness of imidazole derivatives, by contrast with the ineffectiveness of 4,5-diamino-2-(thioalkyl)-6-hydroxypyrimidines, indicates the relative importance of the five-membered ring in the interaction with the enzyme. Moreover, the marked effectiveness of the angularly-cyclized [1,3]thiazino[2,3-i]purinones, which constitute an interesting new class of inhibitors, together with the weak activity of linearly-cyclized derivatives, allowed us to characterize more precisely the lipophilic region of the enzyme facing the N(1)-C(2) positions of the substrate hypoxanthine.

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