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A Facile Synthesis of New Fungitoxic Imidazo-1,3,4-oxa(thia)diazoles and Imidazothiazoles
Yadav, Lal Dhar S.,Vaish, Anjum
, p. 89 - 92 (2007/10/02)
2-amino heterocycles (1-5) containing the amino group as an element of a partial amidine structure reacted with trichloroacetyl chloride and then with primary arylamines to yield the title compounds (11-26) through the ring closure of isolable N-heteroaryltrichloroacetamide intermediates (6-10).Some of the intermediates were also prepared through an alternative pathway involving trichloracetylphenoxyiminocarbonic chloride.Three of the compounds (12, 18 and 21) displayed the in vitro fungitoxicity equivalent to that of a commercial fungicide mancozeb against A. niger and F. oxysporium at 1000 ppm concentration.Key words: fungitoxic imidazo-1,3,4-oxa-(thia)diazoles, imidazothiazoles, amino groups, the in vitro fungitoxicity
