159898-39-2

Upstream product

• 159898-38-1 1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-2-nitro-benzene 
• 106-51-4 p-benzoquinone 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 16090-33-8 2-nitrohydroquinone 
• 185330-16-9 2‐azidobenzene‐1,4‐diol 
• 185330-19-2 2-Azido-1,4-bis-(tert-butyl-dimethyl-silanyloxy)-benzene 

Downstream Products

• 159898-40-5 N-[2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-formamide 
• 155853-15-9 C₁₉H₃₆N₂O₃Si₂ 
• 155853-14-8 [2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amine 
• 151606-30-3 Dephostatin 

Relevant academic research and scientific papers

Efficient Synthesis of Aminonaphthoquinones and Azidobenzohydroquinones: Mechanistic Considerations of the Reaction of Hydrazoic Acid with Quinones. An Overview

Parameters useful to predict and control the reaction outcome of conjugate addition of hydrazoic acid to quinones have been studied, and the optimum conditions for the efficient synthesis of aminonaphthoquinones and azidobenzohydroquinones are reported. The application of this reaction for the efficient formal synthesis of dephostatin is also presented.

Synthesis of Dephostatin, a Novel Protein Tyrosine Phosphatase Inhibitor

The novel protein tyrosine phosphatase inhibitor was synthesized in 6 steps with an overall yield of 35percent from 2-nitrohydroquinone.