159910-01-7

Upstream product

• 13990-96-0 rac-(1S,2S)-dimethyl 4-oxocyclohexane-1,2-dicarboxylate 
• 17081-97-9 methyl (E)-4-chloro-4-oxo-2-butenoate 
• 159759-10-1 (4R,5R,8R,9R)-2,2-Dimethyl-7-oxo-4,5-diphenyl-3,6-dioxa-2-sila-bicyclo[6.3.1]dodec-1⁽¹¹⁾-ene-9-carboxylic acid methyl ester 

Relevant academic research and scientific papers

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is i

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is i

Role of chiral auxiliaries in the type 2 intramolecular Diels-Alder reaction. Influence on diastereoselectivity

The incorporation of a chiral auxiliary as part of a disposable tether in the type 2 intramolecular Diels-Alder cycloaddition leads to a pair of diastereomers. Separation of the diastereomers and tether removal yields enantiomerically pure cyclohexanes and decalins.