159928-92-4

Upstream product

• 500-99-2 3,5-dimethoxyphenol 
• 134-96-3 syringic aldehyde 
• 159928-90-2 4-(4-Formyl-2,6-dimethoxy-phenoxy)-butyric acid methyl ester 
• 211192-57-3 acetic acid 2,6-dimethoxy-4-triisopropylsilanyloxy-phenyl ester 
• 211192-56-2 2,6-dimethoxy-1-O-acetyl-1,4-hydroquinone 
• 205868-66-2 2,6-dimethoxy-4-O-triisopropylsilyl-1,4-hydroquinone 
• 134778-17-9 (3,5-dimethoxyphenoxy)triisopropylsilane 
• 7702-17-2 4-(acetyloxy)-3,5-dimethoxyphenyl acetate 
• 4897-84-1 Methyl 4-bromobutyrate 
• 205868-68-4 2,6-dimethoxy-1-O-(3'-carbomethoxypropyl)-4-O-triisopropylsilyl-1,4-hydroquinone 
• 159928-91-3 4-(4-Formyloxy-2,6-dimethoxy-phenoxy)-butyric acid methyl ester 

Downstream Products

• 159928-93-5 4-[4-(2,4-Dinitro-phenoxy)-2,6-dimethoxy-phenoxy]-butyric acid 
• 205868-69-5 4-[4-(2,6-Dinitro-phenoxy)-2,6-dimethoxy-phenoxy]-butyric acid methyl ester 
• 205868-75-3 4-[4-(2,6-Dinitro-phenoxy)-2,6-dimethoxy-phenoxy]-butyric acid 
• 202126-72-5 4-[4-(2,4-Dinitro-phenoxy)-2,6-dimethoxy-phenoxy]-butyric acid methyl ester 

Relevant academic research and scientific papers

Studies of a novel biomimetic radical spirocyclisation

The mechanism of the radical spirocyclisation 7→9 has been investigated. It has been shown by isotopic labelling that the biaryl ether oxygen does not emerge as the carbonyl group oxygen in the product, nor does the latter arise by hydrolysis of an intermediate e.g. 33 by added water. The mechanism of Scheme 1 path a is proposed, involving oxygen transfer from an aromatic nitro group to carbon in a cyclohexadienyl radical. Radical decarboxylation of the biarylamine derivative 29 does not lead to spirodienone 9 but diverts instead to the azathiaacetal 30.

New carbon radical chemistry as a model for the biogenesis of the interiorin/kadsulignan type of dibenzocyclooctadiene lignan

Novel intramolecular radical spirocyclisation reactions in aromatic nuclei, 48→49, 40→22 and 34→32, are presented, which mimic a key step in the proposed biosynthesis of the interiorins 2a-d, the kadsulignans 3a,b and relatives.

Biomimetic Spirocyclisation using Novel Intramolecular Radical Oxygenation; a Model for the Biosynthesis of the Interiorin Lignans

Novel intramolecular radical spirocyclisation reactions in aromatic nuclei, 22 -> 23 and 30 -> 31, are presented, which mimic a key step in the proposed biosynthesis of the interiorins 1-4 and kadsulignans 5, 6.