159934-01-7Relevant academic research and scientific papers
Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives
-
Page/Page column 9-10, (2008/06/13)
The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.
