159934-11-9Relevant academic research and scientific papers
Unified route to the palmarumycin and preussomerin natural products. Enantioselective synthesis of (-)-preussomerin G
Barrett, Anthony G.M.,Blaney, Frank,Campbell, Andrew D.,Hamprecht, Dieter,Meyer, Thorsten,White, Andrew J.P.,Witty, David,Williams, David J.
, p. 2735 - 2750 (2002)
The total syntheses of eight members of the palmarumycin family have been achieved, with identification of the absolute stereochemistry for three of these natural products. In addition, the ras-farnesyl transferase inhibitor (-)-preussomerin G has been synthesized, achieving the first enantioselective route for accessing this family of natural products. Highlights of the synthetic work include an asymmetric epoxidation of a cyclic enone in excellent yield and enantiomeric excess and a potentially biomimetic oxidative spirocyclization for the introduction of the bis-spiroketal array unique to the preussomerin natural products.
