1599474-16-4Relevant academic research and scientific papers
Preparation and reactions of heteroarylmethylzinc reagents
Barl, Nadja M.,Sansiaume-Dagousset, Elodie,Monzon, Gabriel,Wagner, Andreas J.,Knochel, Paul
, p. 2422 - 2425 (2014)
We report a general preparation of heteroarylmethylzinc chlorides by direct zinc insertion into heteroarylmethyl chlorides, along with a facile and straightforward synthesis of these heterocyclic chloromethyl precursors. We demonstrate that heteroarylmethylzinc reagents undergo various reactions including cross-couplings, allylations, acylations, and addition reactions to aldehydes, leading to polyfunctional heterocyclic products. Furthermore, these heteroaromatic zinc compounds prove to be versatile reagents for the preparation of various N- and O-heterocycles and give access to an analogue of a CB1 modifier.
